摘要
目的:了解可手术的乳腺癌对术前化疗的反应性以及与多药耐药的关系,探讨其机制。方法:将80例Ⅱ期乳腺癌患者随机分为2组,即术前未化疗组和CMF方案化疗组;分别观察其多药耐药基因蛋白(P-gp)的表达情况及与化疗反应的关系,并观察肿瘤体外药敏试验的耐药情况。结果:本组化疗部分缓解和轻度缓解分别为12/40(30.0%)、21/40(52.5%);未化疗组P-gp表达率为22.5%,经化疗后表达率明显升高(P<0.05);对化疗有较好反应的肿瘤,其P-gp多为阳性表达。体外药敏试验显示化疗后肿瘤细胞对长春碱类及蒽环类的耐药比率明显增加(P<0.05)。结论:术前CMF方案化疗有一定疗效,经化疗后残留癌细胞的P-gp表达增加,可能出现交叉耐药性,术后可参考药敏试验选择化疗药物。
Objective:To study the relationship between tumor response to neoadjuvant chemotherapy and multidrug resistance in operable breast cancer.Methods:Eighty patients with newly diagnosed stageⅡbreast cancer were randomly divided into two groups.Group A:No treatment before surgery.Group B:CMF regimen was administered weekly for2weeks,and clin i-cal tumor response to drug was graded.P-glycoprotein(P-gp)expression was detected by im-munohis tochemical technique and chemosensitivity tests by MTT in vitro were observed.Re -sults:The partial response and mild response rates of the chemotherapy group were30.0%and52.5%re spectively.The P-gp expression rate in the non-chemotherapy group was22.5%,but it in creased significantly in the neoadjuvant chemotherapy group(P<0.05).The P-gp expression in the chemotherapy sensitive tumors were more positive.In vitro chemosensitivity test revealed that the ratio of resistance to vinca alkaloids and anthracyclines were increased after chemotherapy(P<0.05).Conclusion:The results showed that preoperative neoadjuvant chemotherapy with CMP regi-men is effective.The P-gp expression increased in the residual tumor cells after chemotherapy.CMP regimen may induce cross resistance to vinca alkaloids and anthracyclines.
出处
《中国肿瘤临床》
CAS
CSCD
北大核心
2002年第4期255-257,共3页
Chinese Journal of Clinical Oncology
关键词
乳腺癌
术前化疗
化疗反应
多药耐药性
Breast cancer Neoadjuvant chemotherapy Response Multidrug resistance
