摘要
检测１７０例原代乳腺癌细胞对常用化疗药物的体外敏感性。发现：①乳腺癌细胞对５－氟脲嘧啶（５－Ｆｕ），丝裂霉素Ｃ（ＭＭＣ），顺铂（ＤＤＰ）及泰素（ｔａｘｏｌ）的高度敏感率（ＨＳＲ）明显高于其它受试药物（Ｐ＜０．０５）；②药物敏感性与乳癌的病理分型和临床分期、以及雌激素受体（ＥＲ）和表皮生长因子受体（ＥＧＦＲ）表达状况无明显关系（Ｐ＞０．０５）；
We tested the in vitro sensitivity of 170 primary breast carcinoma samples to the anti cancer drugs conventionally used in clinical chemotherapy. It was found that: ① The high sensitivity rate(HSR) of breast carcinoma cells to 5 fluorouracil(5 Fu), mitomycin(MMC), cisplatin(DDP), adriamycin(ADM), methotrexate(MTX), vincristin(VCR), vepesid(VP 16), taxol, and vindesine(VDS) were 57.1%, 49.4%, 48.3%, 35.8%, 21.8%, 21.2%, 10%, 18.2% and 20.9%, respectively. The increase of HSR of cancer cells to 5 Fu, MMC, DDP, taxol was more significant than that of the other drugs tested (P<0.05). ② No correlation was shown between drug sensitivity and factors, i.e. pathological type, clinical type, expression of estrogen receptor(ER) and epithelium growth factor receptor(EGFR) for breast carcinoma (P>0.05). ③ Cyclosporin A can increase part of the sensitivity of ADM resistant breast carcinoma cells to ADM.
出处
《湖南医科大学学报》
CSCD
1998年第6期531-534,共4页
Bulletin of Hunan Medical University
关键词
乳腺癌
药物敏感性
药物耐受性
药物疗法
breast neoplasms
carcinoma
drug sensitivity
drug tolerance
drug therapy
in vitro
