摘要
目的 :探讨痛经灵颗粒治疗子宫内膜异位症的临床疗效及机理。方法 :将子宫内膜异位症患者随机分为两组 ,用痛经灵颗粒和他莫西芬进行治疗。观察其临床疗效。结果 :痛经灵颗粒和他莫西芬治疗子宫内膜异位症总有效率分别为93.33%,88.33%;妊娠率 5 5 .5 6 %,35 .2 9;治愈率 38.33%,2 0 .0 0 %。两组比较治愈率有显著性差异 (P <0 .0 5 ) ,其辨证分型与临床疗效间比较有显著性差异 (P <0 .0 5 )。痛经灵颗粒组对渐进性痛经的治愈率为 44 .0 7%,明显高于他莫西芬组 ,两组比较有显著性差异 (P <0 .0 5 ) ,用痛经灵颗粒可使月经紊乱的治愈率达 83.33%,而他莫西芬组用药后月经量明显减少 ,甚至于闭经。痛经灵颗粒长期用药未发现毒副作用 ,且能调节月经紊乱。结论 :痛经灵颗粒可作为治疗子宫内膜异位症的药物应用于临床。
Objective:To study the clinical effect and machanism of Tongjinglin Granules for endometriosis.Methods: Patients with endometriosis were divided into two groups, treated with Tongjinglin Granules and Tamoxifen citrate, respectively.Results: The total effective rates were 93.33% for Tongjinglin group and 88.33% for Tamoxifen citrate group in treating endometriosis. The pregnancy rates were 55.56% and 35.29%, respectively. The cure rates were 38.33% and 20.00%,respectively. There were significant differences between two groups in the cure rate (P<0.05),also in clinical effect according to pattern identification and types of TCM(P<0.05). The cure ratc of Tongjinglin Granules in progressive dysmenorrhea was 44.07, higher than Tamoxifen citrate group. The significant difference existed between two groups (P<0.05). The cure rate of Tongjinglin Granules for menstrual disorder was up to 83.33%, but patients'menstruation obviously reduced after they take Tamoxifen citrate, even amenia occured. No toxicity and side effects were observed in long-term use of Tongjingun Granules. It also can regulate menstrual disordar. Conclusion:Tongjinglin Granules can be effective for endometriosis
出处
《中成药》
CAS
CSCD
北大核心
2002年第4期274-277,共4页
Chinese Traditional Patent Medicine
