摘要
目的 :评定硫酸吗啡控释片 (MST)直肠给药对中、重度癌性疼痛的镇痛疗效。方法 :采用自身对照法。 48例伴有中、重度癌性疼痛病人先口服MST6天 ,然后改为MST直肠给药 6天。结果 :MST直肠给药有效率和显著有效率 (明显缓解 +完全缓解 )分别为 95 83%与 81 2 5 %。治疗后疼痛明显减轻 ,生活质量明显提高 ,直肠给药与口服给药相比疗效无显著差异 (P >0 0 5 )。副作用与口服给药相同 ,主要为嗜睡、恶心、呕吐、便秘。结论 :MST直肠给药具有良好镇痛效果 ,尤其适合于不能口服给药的晚期癌症患者。
Objective:To evaluate the analgesis effect of morphine sulfate Controlled release tablets (MST) administered rectal in patients with moderate or severe Cancer pain.Methods:Forty eight patients with moderate or Severe cancer pain were treated with controlled release MST for 12 days. MST was given orally for the first 6 days and then rectally.Results:The total response rate and the significant response rate are 95 83% and 81 25% respectively. After treatment, the pain alleviated significantly and life quality improved markedly. Rectal administration had no Significant difference as compare with oral administration in efficacy ( P >0 05) and they had same side effects as lethargy, nausea, Vomiting and constipation. No more dosage should be added when oral administration was changed by rectal administration.Conclusion:Rectal administration of MST has remarkable efficacy in cancer pain relief, especially for those cancer of late stage patients to whom oral administration is not available.
出处
《临床肿瘤学杂志》
CAS
2002年第2期121-123,共3页
Chinese Clinical Oncology
关键词
硫酸吗啡控释片
癌性疼痛
直肠给药
疗效
Morphine sulfate controulled release
Cancer pain
Rectal administraion
Efficacy
