摘要
目的:研究龙眼叶不同提取物对α-葡萄糖苷酶的抑制活性。方法:通过建立体外α-葡萄糖苷酶抑制模型,对龙眼叶提取物进行活性筛选,并对提取物浓度与抑制活性关系进行研究。结果:龙眼叶乙酸乙酯提取物(IC_50=0.105 2mg/mL)和正丁醇提取物(IC_50=0.1261mg/mL)均有较好的α-葡萄糖苷酶抑制作用,抑制活性大于阳性对照药阿卡波糖(IC_50=0.1960mg/mL),且抑制活性呈浓度依赖性。结论:龙眼叶乙酸乙酯和正丁醇提取物对α-葡萄糖苷酶活性有抑制作用,具有开发治疗糖尿病降血糖药物的价值。
Objective:To study theα-glucosidase inhibitory activity of extracts from the leaf of Dimocarpus longan Lour.Methods:By establishingα-glucosidase inhibitory model in vitro,the activity of extracts from the leaf of Dimocarpus longan Lour was screened,and the inhibitory activity was studied between different concentration of the extracts.Results:The ethyl acetate extract(IC50=0.1052 mg/mL)and n-butanol extract(IC50=0.1261 mg/mL)from the leaf of Dimocarpus longan Lour showed good nhibitory activity,which showed greater activity than that of acarbose(IC50=0.1960 mg/mL).Theα-glucosidase inhibitory activity had concentration-dependent manner.Conclusion:The ethyl acetate extract and n-butanol extract from the leaf of Dimocarpus longan Lour showed very significant inhibitory activity toα-glucosidase,and could be exploited the diabetes drugs asα-glucosidases inhibitors in future.
作者
黄春燕
梁洁
黄团心
麦嘉妮
徐晖
杨川川
Huang Chunyan;Liang Jie;Huang Tuanxin;Mai Jiani;Xu Hui;Yang Chuanchuan(Guangxi University of Chinese Medicine,Nanning 530200,China;Guangxi Institute for Food and Drug Control,Nanning 530021,China)
出处
《亚太传统医药》
2019年第1期7-9,共3页
Asia-Pacific Traditional Medicine
基金
国家自然科学基金(81560691)
广西中医药大学中药学博士点建设工程开放课题(201410-06)
广西中医药大学"岐黄工程"高层次人才团队培育项目(No.2018002)
壮瑶药协同创新中心(桂教科研[2013]20号)
广西壮瑶药重点实验室项目(桂科基字[2014]32号)
国家中医药管理局科研三级实验室中(壮)药化学与质量分析实验室项目
广西高校中药提取纯化与质量分析重点实验室项目
关键词
龙眼叶
Α-葡萄糖苷酶
抑制活性
The leaf of Dimocarpus longan Lour
α-glucosidase
Inhibitory Activity
