摘要
目的研究眼用银黄温敏凝胶的制备工艺。方法以泊洛沙姆407、泊洛沙姆188用量为考察指标,以胶凝温度为考察指标,采用星点设计-效应面法筛选银黄温敏凝胶处方,并对其他辅料因素进行考察,确定眼用银黄温敏凝胶的最佳制备工艺。结果眼用银黄温敏凝胶最佳处方为:泊洛沙姆407用量20%,泊洛沙姆188用量1%,透明质酸用量0.1%,苯扎氯铵用量0.01%,乙二胺四乙酸用量0.02%。结论眼用银黄温敏凝胶制备工艺简单,稳定性好,相变温度适宜。
Objective To optimize the preparation technology of thermo-reversible Yinhuang opthalimic gel by the central composite design-response surface method.Methods The poloxamer 407 and poloxamer 188 were used as the investigation factors,and the evaluation index was the gel temperature. Central composite design-response surface method was used to evaluate the mathematic relation between the evaluation index and tow investigation indexes to identify the optimum prescription.Results According to the quadratic models,it was found that there was reliable quantitative relation between the evaluation index and two investigation indexes,among which the optimun dosage was 20% for P407,1% for P188,0.1% for hyaluronic acid,0.01% for benzalkonium chloride,0.02% for EDTA.Conclusions This method is reliable and feasible,whicn can realize the prescription optimization of the gel.
作者
陈智
叶思勇
Chen Zhi;Ye Siyong(College of Pharmacy,Shandong University of Traditional Chinese Medicine,Jinan 250355,China;Pharmacy Department,the Second People's Hospital of Jinan,Jinan 250001,China)
出处
《国际中医中药杂志》
2019年第1期67-71,共5页
International Journal of Traditional Chinese Medicine
基金
山东省自然科学基金(ZR2017LH070)
山东省高等学校科技计划项目(J17KA245).
关键词
凝胶剂(中药)
星点-设计响应面法
泊洛沙姆
剂型改进
Gels (TCD)
Central composite design-response surface method
Poloxamer
Dosage forms improving
