摘要
目的 探讨中医证型、血清胱抑素C和超敏C反应蛋白与高血压患者发生脑梗死的相关性.方法 将80例原发性高血压患者根据脑梗死发病情况分为高血压组38例和脑梗死组42例.结合两组患者临床症状进行中医分型,测定两组血清胱抑素C和超敏C反应蛋白水平及其他生化指标.比较不同中医证型和兼证个数与脑梗死发生的相关性,比较两组患者血清胱抑素C和超敏C反应蛋白水平与发生脑梗死的相关性.结果 脑梗死组患风火上扰证、风痰瘀阻证、痰热腑实证发生率显著高于高血压组(P<0 .05) ,气虚血瘀证发生率显著低于高血压组(P<0 .05) ,两组阴虚风动证发生率比较差异无统计学意义(P>0 .05) .高血压组单证患者显著多于脑梗死组(P<0 .01) ,脑梗死组三证相兼患者显著多于高血压组(P<0 .01).风火上扰证、风痰瘀阻证、痰热腑实证和兼证个数与脑梗死发生呈显著正相关(P<0 .05) ,气虚血瘀证与脑梗死发生呈显著负相关(P<0 .05) ,阴虚风动证与脑梗死发生无显著相关性(P>0 .05).脑梗死组血清胱抑素C和超敏C反应蛋白浓度均显著高于高血压组(P<0 .01) ,血清胱抑素C和超敏C反应蛋白呈显著正相关(P<0 .05) .结论 中医证型、血清胱抑素C和超敏C反应蛋白水平与高血压患者脑梗死发生具有显著相关性,对于评估高血压患者脑梗死发生风险具有积极意义.
Objective To study the correlation between traditional Chinese medicine (TCM)syndrome, Cystain C,high sensitivity C-reactive protein and cerebral infarction in patients with hypertension.Methods 80 cases of patients with essential hypertension were divided into hypertension group (38 cases)and cerebral infarction group (42 cases)according to the incidence of cerebral infarction.Combined with the clinical symptoms of the two groups of patients,the levels of serum cystatin C and high-sensitivity C-reactive protein and other biochemical indicators were determined.The correlation between different TCM syndrome types,the number of concurrent syndromes and the occurrence of cerebral infarction were compared.The correlation between serum cystatin C,high-sensitivity C-reactive protein levels and cerebral infarction was compared between the two groups.Results The incidence of stagnation syndrome,wind-stagnation syndrome,and phlegm-heat sputum in the cerebral infarction group was significantly higher than that in the hypertension group (P<0.05),the incidence of Qi deficiency and blood st'asis syndrome was significantly lower than that of hypertension group (P<0.05).There was no significant difference in the incidence of yin deficiency and wind-induced syndrome between the two groups (P>0.05).The number of patients with hypertension in the hypertension group was significantly higher than that in the cere- bral infarction group (P<0.01).The number of patients with three syndromes in the cerebral infarction group was significantly more than that in the hypertension group (P<0.01).There was a significant positive correlation between stagnation syndrome,wind-stagnation syndrome,phlegm-heat sputum,the number of concurrent syndromes and cerebral infarction (P<0.05).There was a significant negative correlation between qi deficiency and blood stasis syndrome (P<0.05).There was no significant correlation between yin deficiency and wind-stagnation syndrome and cerebral infarction (P>0.05).The levels of serum cystatin C and high-sensitivity C-reactive protein in the cerebral infarction group were significantly higher than those in the hypertension group (P<0.01).There was a significant positive correlation between serum cystatin C and high-sensitivity C-reactive protein (P<0.05).Conclusion TCM syndrome type,serum cystatin C and high-sensitivity C-reactive protein levels are significantly associated with cerebral infarction in patients with hypertension,and have positive significance in assessing the risk of cerebral infarction in patients with hypertension.
作者
王芸生
牛永义
Wang Yunsheng;Niu Yongyi(General Hospital of Pingmei Shenma Medical Group,Pingdingshan 467000,Henan,China)
出处
《临床心身疾病杂志》
CAS
2019年第1期103-105,140,共4页
Journal of Clinical Psychosomatic Diseases
关键词
高血压
脑梗死
中医证型
胱抑素C
超敏C反应蛋白
Hypertension
cerebral infarction
TCM syndrome
cystatin C
hypersensitive C-reactive pro-tein
