摘要
目的 :探讨急性心肌梗死 (AMI)患者溶栓后降钙素基因相关肽 (CGRP)和内皮素(ET)的变化。方法 :将 4 5例AMI患者根据溶栓情况分为常规治疗组、溶栓未通组和溶栓再通组 ,用放射免疫法测定 3组患者梗死后不同时间 (4、6、8、10、12、14、2 4、16 8h)的血浆CGRP和ET水平。结果 :溶栓再通组血浆CGRP和ET峰值显著高于常规治疗组和溶栓未通组 (P <0 .0 1) ,且峰值出现时间提前 2h。结论 :AMI患者溶栓再通后CGRP和ET峰值提高 ,且时间提前 ,CGRP和ET可作为溶栓再通和评价梗死范围的一种有价值的指标。
Objective: To investigate the changes of calcitonin gene-related peptide (CGRP) and endothelin (ET) in patients with acute myocardial infarction (AMI) after thrombolysis. Method:Forty-five patients with AMI were divided into three groups: conventional treatment group, non-reperfusion group and reperfusion group. Plasma CGRP and ET were measured after AMI at 4, 6, 8, 10, 12, 14, 24 and 168 hours using radioimmunoassay. Result:The peak level of plasma CGRP and ET were significantly higher in the reperfusion group after thrombolys than that in normal treatment and non-reperfusion group (P< 0.01) and the peak level was 2 hours earlier. But plasma level of CGRP and ET decreased quickly 10 hours after AMI in the reperfusion group. Conclusion:CGRP and ET can be regarded as markers of reperfusion after thrombolysis in patients with AMI.
出处
《临床心血管病杂志》
CAS
CSCD
北大核心
2002年第3期117-119,共3页
Journal of Clinical Cardiology
关键词
急性心肌梗死
血栓溶解治疗
降钙素基因相关肽
内皮素
Myocardial infarction
Thrombolytic therapy
Calcitonin gene-related peptied
Endothelin
