摘要
目的 :了解慢传输性便秘 (STC)结肠壁神经系统的病理改变。方法 :用免疫组化法检测了慢传输性便秘病人结肠肠壁神经元凋亡现象。结果 :STC患者结肠壁神经元有凋亡现象发生 ,神经元内 bcl- 2含量下降 ,而 bax无显著变化。结论 :这种不恰当的细胞死亡——病理性神经元凋亡可能在 STC的发病过程中具有重要意义 ,提示通过抑制凋亡的发生是预防和治疗 STC的一个有效途径。
Objective:To study further about the mechanism and pathophysiology of STC.Methods: Apoptosis in neurons of colon were studied imunohistochemicaly.Results: In STC,there is apoptosis phenomenen,the content of bcl-2 is reduced sigificantly and the change of Bax is not significant in colonic neurons compared to control group.Conclusion: This kind of pathologic neuron apotosis is very important in STC mechanism.It indicated that inhibiting apoptosis in neurons may be an effective mathod for preventing and treating STC.
出处
《大肠肛门病外科杂志》
2002年第1期17-19,共3页
Journal of Coloproctological Surgery
