摘要
目的 探讨冠心病患者血清心肌肌钙蛋白I(cTnI)水平与远期心脏事件的相关性。方法 测定 16 6例冠心病患者的血清cTnI、肌酸激酶同工酶 ,根据cTnI的值分为二组 ,根据临床资料、冠状动脉造影结果 ,随访患者远期心脏事件 ,分析cTnI与心脏事件的相关因素及它们的关系。结果 16 6例患者中有 5 8例cTnI升高 ,4例肌酸激酶同工酶轻度升高 ,cTnI升高与心电图出现异常Q波、ST段改变关系有统计学意义 (P <0 0 5 ) ;cTnI升高组糖尿病患者数明显低于cTnI正常组 (P <0 0 5 ) ;15 9例近期存活者中 15 1例进行了远期随访 ,随访时间为 (2 6± 10 )个月 ,共有 2 7例患者发生心脏事件32例次 ,其发生与cTnI升高关系有统计学意义 (P <0 0 5 )。结论 血清cTnI是心肌损伤敏感而特异性的指标 ,是冠心病患者远期心脏事件的独立预测因子。
Objective To investigate the correlation of serum cardiac troponin I (cTnI)and the late heart events in patients with coronary heart disease(CHD) Methods Serum cTnI and creatine kinase isoenzyme MB in 166 patients with CHD were measured These patients were grouped according to levels of cTnI, the general clinic data, results of coronary arteriography and electrocardiogram were recorded, and late events were followed up The correlative factors of cTnI level with heart events and their relationship were analyzed Results In 58 of 166 patients cTnI levels elevated, which positively correlated with the abnormal Q wave, ST segment deviation in electrocardiogram and non diabetes ( P <0 05), while in only 4 of 166 cases creatine kinase isoenzyme MB levels slightly elevated The late follow up [(26±10) months]was finished in 151 patients among 159 survivals Thirty two heart events in 27 patients were recorded, which positively correlated with cTnI elevation ( P <0 05) Conclusion Serum cTnI is a higher sensitive and specific marker for mimor myocardial damage, and could be an independent indicator of late heart events in patients with CHD
出处
《中华心血管病杂志》
CAS
CSCD
北大核心
2002年第3期149-151,共3页
Chinese Journal of Cardiology
