摘要
目的观察血清心肌肌钙蛋白I(cTn-I)及肌酸激酶同功酶(CK-MB)对老年(65岁及65岁以上)急性心肌梗死(AMI)的早期诊断价值.方法用酶联免疫分析法分别测定30例老年和30例中年(65岁以下)AMI患者0～4 h、24 h以内、48 h、72 h及1周后的cTn-I,同时用自动生化仪测定以上各时间点CK-MB值.结果老年患者中,0～4 h内及1周后血清cTn-I超过正常参考值范围者分别为70%和50%.而CK-MB超过正常参考值范围者分别为17%和10%.中年患者中,0～4 h内及1周后CK-MB超过正常参考值范围者分别为23%和6%.而血清cTn-I超过正常参考值范围者分别占63%和60%.结论早期诊断老年和中年AMI,血清cTn-I较CK-MB更为敏感.尤其对老年人症状不明显者,更有意义.
Objective To observe the value of serum cardiac troponin Ⅰ(cTn-Ⅰ) on the diagnosis of acute myocardial infarction (AMI). Methods The serum cTn-Ⅰand CK-MB of 30 elderly patients(≥65 y) and 30 middle-aged patients(<65y) with AMI were measured by enzyme immunoassay during 0～4 h and within 24 h, after 48 h, 72 h and one week, respectively. Results Higher serum cTn-Ⅰin 70% of 30 elderly patients and 60% of 30 middle-aged patients with AMI were observed during 0～4 h; the value of serum cTn-Ⅰin 50% of 30 elderly patients and 60% of 30 middle-aged patients with AMI were still higher than normal values after one week. The values of serum CK-MB in 17% of 30 elderly patients and 23% of 30 middle-aged patients with AMI were higher than normal values during 0～4 h. The values of serum CK-MB in 10% of 30 elderly patients and 6% of 30 middle-aged patients with AMI were higher than normal value after one week. Conclusion Serum cTn-I and CK-MB are of the same clinical significance on the early diagnosis of elderly AMI; serum cTn-I is more sensitive than CK-MB on the diagnosis of early phase of AMI, particularly, in the elderly.
出处
《西安交通大学学报（医学版）》
CAS
CSCD
北大核心
2005年第2期158-159,175,共3页
Journal of Xi’an Jiaotong University（Medical Sciences）
基金
陕西省自然科学基金资助(No.2001SM78)
