摘要
目的 探讨头孢替唑钠的结晶特性。方法 利用单晶X射线衍射、粉末X射线衍射、DSC和TGA等理化分析方法 ,分析不同条件得到的头孢替唑钠晶体。结果 头孢替唑钠晶体为头孢替唑钠一水合物 ,至少有I型和II型两种不同的晶型 ;水分子在不同的头孢替唑钠晶格中有不同的结合状态。结论 不同结晶条件下得到的头孢替唑钠一水合物的晶格结构略有差异 ,并影响晶体的热稳定性。
AIM To study the crystalline characteristics of ceftezole sodium. METHODS Ceftezole sodium crystals were obtained from different solvents. X ray diffraction, DSC, TGA, etc were used to analyze the crystals. RESULTS Ceftezole sodium crystal was easily obtained in isopropanol water mixture. It consists of ceftizole sodium monohydrate, which consists of type I and type II two different crystal forms. Powder X ray diffraction patterns showed differences between type I and the type II crystal forms. Peaks at 8° and 18° in diffractograms of the type I, but at 9° and 18 6° in the type II could be observed. Water molecules in different crystal forms had different combining condition. They lost during 35～117℃ in the type I form, but lost during 110～160℃ in the type II form. CONCLUSION Structure of ceftizole sodium monohydrate crystal obtained in different circumstance could be some vary, which influence upon the thermal stability of the compound. The type I crystal form is more stable than the type II.
出处
《药学学报》
CAS
CSCD
北大核心
2002年第4期275-279,共5页
Acta Pharmaceutica Sinica
