摘要
目的 探讨消化系多原发癌的发病特点、诊治原则及预后。方法 通过计算机病案管理系统 ,检索 10年间收治的全部消化系恶性肿瘤病例 ,对检出的 116例多原发癌患者的临床资料进行回顾性分析。结果 消化系多原发癌 116例 ,其中双原发癌 111例 ,三原发癌 5例 ,总发病率为1.7% ,男女之比为 2 .7∶1。其中同时性多原发癌 6 2例 ,异时性多原发癌 5 4例。全部癌灶中受累及次数为 :结肠 >胃 >直肠 >肝 ,结肠病灶中又以右半结肠最多。以 1990～ 1995年有完整随访记录的 4 7例计算生存率 ,同时性多原发癌 1,3,5年生存率分别为 4 2 .3%、2 3.1%和 11.5 % ,异时性者为 95 .2 %、85 .7%和 76 .2 %。结论 消化系多原发癌好发于结肠系 ,以右半结肠为著 ;异时性癌预后好于同时性癌 ,两癌间隔时间越长则预后越好 ;均发生于结肠系者预后较好。提高疗效的关键在于早诊早治 。
Objective To study the clinic al characteristics, diagnosis, strategy of treatment and prognosis of multiple p rimary cancers in the digestive sy stem. Methods All malignant lesions in the digestive sy stem enc ountered in the past 10 y ears were analy sed by a computer software. Results 116 cases of multiple cancers were observed with an incidence of 1.74%. Male to female ratio was 2.7∶1. There were 62 sy nchrono us carcinomas and 54 metachronous ones. In decreasing sequence, they were: colon >stomach>rectum>liver. The 1 , 3 and 5 y ear survival rates of the sy nchronous ones were 42.3%, 23.1% and 11.5%. Those of metachronous ones were 95.2%, 85.7% and 76.2%. Conclusion High frequency of multiple primary cancers is found in the colon, especially over the right side. Metachronous carcinomas usua lly give better prognosis than the sy nchronous ones. The longer the interval bet ween the development of the two primary lesions, the better the prognosis. Multi ple cancers of the colon have satisfactory prognosis. The Subject to improve the tre atment is to be vigilant against lesions in the digestive tract so as to arrive at a timely diagnosis and treatment. The strategy of combining radical treatment with immuno supportive therapy is advocated. [
出处
《中华肿瘤杂志》
CAS
CSCD
北大核心
2002年第2期191-193,共3页
Chinese Journal of Oncology
