摘要
目的 探讨三原发癌的临床特点及多器官衰竭对预后的影响。方法 分析从1980年至2002年22年间收治的73例多原发癌中18例三原发癌发生部位、发病年龄、病因、间隔时间、预后。结果 65％的实体瘤发生在消化系统,首癌、次癌、第三癌发病年龄分别为66岁、72岁、78.5岁;第一原发癌和第二原发癌间隔中位时间为70个月,第二原发癌和第三原发癌间隔中位时间为36个月。首癌5年生存率89％;第三原发癌3年和5年生存率分别为44％,11％。死亡14例,其中7例死于多器官衰竭。结论 消化道是多原发癌好发部位,放、化疗是发生多原发癌的重要诱因;多器官衰竭致死是影响多原发癌患者长期生存的重要原因。
Objective To elucidate the clinical picture of triple primary carcinomas and to explore the prognostic relation between multiple organ failure (MOF) and multiple primary malignant tumors (MPMTs) in the elderly. Methods Eighteen patients with triple malignant tumors were analyzed retrospectively. The patients were admitted to this department from 1980 to 2002, accounting for 25% of all hospitalized patients with MPMTs in the same period. Of them 17 were males and one was female. Results There were 52 solid tumors and two malignancies of hematopoietic system. Digestive tract cancers accounted for 65% of the multiple primary cancers in this series. The median age at first, second and third diagnosis was 66, 72 and 78. 5 years, respectively. The 5-year survival rate for patients with initial primary cancer was 89% , and the 3- and 5-year survival rate for patients with third primary cancer was 44% and 11%, respectively. Median survival time was 15 months (ranging from 1 month to 78 months) in fatal patients and 37 months (ranging from 3 months to 120 months) in patients alive and well. Seven of fourteen deaths were directly related to multiple organ failure. Conclusions MPMTs in the gastrointestinal tract are common phenomena. Radiotherapy and chemotherapy are important factors for MPMTs. Death due to multiple organ failure is an important cause affecting long survival of patients with MPMTs.
出处
《中华老年多器官疾病杂志》
2003年第2期127-129,共3页
Chinese Journal of Multiple Organ Diseases in the Elderly
