摘要
目的 :探讨载有转化生长因子 β1(TGF- β1) ,具有高生物活性复合人工骨修复骨缺损的价值。方法 :建立SD大鼠下颌骨缺损模型。采用组织学和分子生物学 Slot Blot杂交法 ,检测羟基磷灰石复合 TGF- β1实验组 ,单纯羟基磷灰石对照组 ,无材料修复的空白对照组在骨缺损愈合过程中的组织学及 型胶原 m RNA的表达状况。结果 :实验组的新骨形成及 型胶原 m RNA的表达水平最高。结论 :提示载有 TGF-
Objective: To assese the value and clinical significance of bioactive material hydroxyapatite (HA) combined with TGF β1 in bone defect healing. Methods: The applicability of bioactive material HA granules combined with TGF β1 (group A) as a substitute for bone graft was observed in SD rat model. The results were compared with those of HA granules (Group B) and ungrafted bone defect (Group C). Results: Group A demonstrated the highest level of type Ⅰ collagen mRNA during healing period. Conclusion: The bioactive material HA combined with TGF β1 can efficiently bond to ongrowing new bone comparing to HA granules.
出处
《浙江大学学报（医学版）》
CAS
CSCD
2002年第1期30-32,共3页
Journal of Zhejiang University(Medical Sciences)
基金
卫生部 (96 2 319)
浙江省卫生厅基金项目
