摘要
应用血清Ⅲ型前胶原（ＰＣⅢ）放免法试剂盒检测急、慢性肝炎及肝硬化患者６１６例血清ＰＣⅢ含量，其中１０２例作了肝活检，病理改变用记分判定。结果发现：与健康对照比较，急性肝炎、慢迁肝、慢活肝及肝硬化患者血清ＰＣⅢ含量均明显升高，差异显著（Ｐ＜０．０５～０．００１）。其升高的血清ＰＣⅢ与肝细胞坏死的范围及门管区炎症程度无相关性（ｒ＝０．４９４；Ｐ＞０．０５），而与肝纤维化程度呈密切正相关（ｒ＝０．６６８；Ｐ＜０．０１）。提示血清ＰＣⅢ测定有助于肝炎，肝硬化时肝纤维化程度的判断。
The serum precollagen type Ⅲ(PCⅢ)of 616 patients with acute hepatitis,chronic hepatitis and hepatic cirrhosis were determined by RIA kit. Among them 102 liver biopsies were obtained and observed by calculation of score.The results showed that the serum PCⅢ levels of the patients with acute hepatitis,chronic persistent hepatitis ,chronic active hepatits and hepatic cirrhosis were all significantly higher than normol control.The levels of serum PCⅢ were not related to the area of necrosis of hepatocyte and the grade of inflamation of portal area,(r=0.494;P>0.05)but positively closely related to the grade of hepatic fibrosis(r=0.668; P<0.01).It suggests that the determination of serum PC Ⅲis useful in the diagnosis of degree of hepatic fibrosis of hepatitis or cirrhosis.
出处
《胃肠病学和肝病学杂志》
CAS
1994年第4期288-291,共4页
Chinese Journal of Gastroenterology and Hepatology
