摘要
为阐明及防治烧伤后负氮平衡提供理论依据 ,在接近体内环境下于体外用免疫沉淀扣除法检测 30 %体表皮肤全层烫伤大鼠伤后第 1、2、3、5、7天内骨骼肌中 2 6S蛋白酶复合体及 19S调节复合体活性的变化。结果发现 ,从烫伤后第 2天开始 ,大鼠骨骼肌中 2 6S蛋白酶复合体及 19S调节复合体的蛋白酶活性和ATPase活性均明显增加 ,提示烧伤可激活 2 6S蛋白酶复合体系统 ,从而参与骨骼肌蛋白质的降解作用 。
To elucidate the mechanism of negative nitrogen balance after burns, immuno precipitation deduction was used to observe the changes in the activity of 26S proteasome and 19S regulator in skeletal muscle of rats inflicted with 30%TBSAⅢ o burns. The protease activity, ATPase activity of 26S proteasome,as well as 19S regulator in skeletal muscle of rats were markedly enhanced on the second day after scald. It is suggested that burn injury could activate the 26S proteasome in skeletal muscle, in turn enhance the degradation of protein , which is associated with negative nitrogen balance following scald
出处
《解放军医学杂志》
CAS
CSCD
北大核心
2002年第3期241-243,共3页
Medical Journal of Chinese People's Liberation Army
