摘要
目的：了解南京市区妇女骨丢失率及骨吸收指标与绝经时间的关系，为早期防治骨质疏松提供依据。方法：随机测定５７６例妇女骨吸收指标尿吡啶酚（Ｐｙｒ）浓度，其中２３３例同时测量腰椎２～４、左髋部股骨颈骨密度。按中青年、围绝经期、绝经早期、绝经晚期分４组。结果：①腰椎２～４、股骨颈骨密度年下降率：围绝经期与绝经前相似为０．６％、０．５％；绝经早期为２．３％、０．９％；绝经晚期为１．０％、１．６％。②围绝经期、绝经早期及绝经晚期与中青年尿Ｐｙｒ／Ｃｒ（肌酐）比较均升高，差异有显著性（Ｐ＜０．０１），后３组间比较差异无显著性（Ｐ＞０．０５）。各组骨质疏松伴发率分别为０、２．２％、２２．８％、６７．６％。③围绝经期及其后妇女中，骨量正常、骨量减少及骨质疏松３组间尿Ｐｙｒ／Ｃｒ比较差异无显著性（Ｐ＞０．０５）。结论：①围绝经期及其后妇女骨吸收指标处于稳定的高水平。②围绝经期骨丢失率与绝经前相当；绝经早期妇女以松质骨为主的腰椎骨量丢失最快，以后下降处于稳定状态；随年龄增长，股骨颈骨量年丢失率逐渐增加。③骨密度与骨吸收指标之间无相关关系。
Objective:To probe the relation among bone loss rate, bone-resorptive biochemical marker and the time of menopause in Nanjing women. Methods:Forty young healthy women (mean age 31.2 years), 120 peri-men opause women (mean age 48.3 years), 172 recent postmenopausal women (the menopause per iod≤5 years) and 244 late postmenopausal women (the menopause periods＞5 years) we re enrolled in this study. The urinary pyridinoline concentrations (Pyr/Cr), bon e-resorptive biochemical marker, of all the 576 cases were measured by EIA, the bone mineral density (BMD) of L2～4 and femoral neck (FN) in 233/576 case s were determined by dual energy X-ray absorptiometry (DEXA). Results:①The reduction of BMD of L2～4 and FN were 0.6% and 0.5% in perimenopau sal women, 2.3% and 0.9% in recent postmenopausal women, 1.0% and 1.6% in late postmenopausal woman respectively. ②The urinary Pyr/Cr of perimenopausal, earl y postmenopausal and late postmenopausal women were similar (P＞{0.05)}, b ut all higher than that of young women respectively (all, P＜0.01). ③In per imenop ausal, early and late postmenopausal women, the urinary Pyr/Cr among the women w ith normal BMD, osteopenia and osteoporosis were no significantly different (P ＞0.05). Conclusion:①The bone loss of lumbar veterbrae in recent po stmenopausal women in the most, and it declined steady in later, while that of FN gradually decreased with aging. ②The bone resorption is constantly increased after perimenopause. ③There is no closely relation between the urinary Pyr/Cr and BMD.
出处
《南京医科大学学报（自然科学版）》
CAS
CSCD
北大核心
2002年第2期141-143,共3页
Journal of Nanjing Medical University(Natural Sciences)
