摘要
目的 研究血小板活化因子测定与肝纤维化疾病的临床意义 ,了解肝脏受损在肝纤维化患者微循环改变中的作用。方法 采用固相免疫放射法检测各期肝纤维化患者和正常人血浆血小板活化的血栓素 (TXB2 )、6 酮 前列腺素 ( 6 K PGF1α)、α 颗粒膜蛋白 (GMP 14 0 )这三项指标的水平。结果 肝纤维化患者TXB2 、GMP 14 0、TXB2 6 K PGF1α的水平较正常人显著升高 ,6 K PGF1α显著下降。结论 各期肝纤维化患者存在不同程度微循环障碍 ,肝纤维化程度越重TXB2 、GMP 14 0、TXB2 6 K PGF1α值越大 ,6 K PGF1α值越小 ,微循环障碍越重。检测以上几项指标可为临床肝纤维化提供辅助诊断依据 ,使肝纤维化患者及早得到诊断 。
Objective To study be relationship between platelet activating factor and liver fibrosis,and to learn the effect of injured liver on the iicrocycle alteration in patients with liver fibrosis.Methods TXB 2, 6 K PGF 1α ,GMP 14 in platelet were detected in patients with liver fibrosis at different periods and in healthy people by enzyme linked immunosorbent assay.Results The livel of TXB 2,GMP 140 and TXB 2/6 K PGF 1α were significantly increased in patients with liver fibrosis,as compared with those in healthy people,whereas 6 K PGF 1α was notably decreased.Conclusion There is microcycle obstacle in patients with liver fibrosis at different periods,the more serious the fibrosisis,the higher level of TXB 2,GMP 140 and TXB 2/6 k PGF 1α will be;the lower level of 6 K PGF 1α is,the more serious microcycle obstacle will be.The detect these indexes can provide an auxiliary dignostic reference and find out the patients with liver fibrosis as early as possible,so as to make an effective prevention.
出处
《河北医药》
CAS
2002年第1期16-17,共2页
Hebei Medical Journal
