摘要
目的 研究阳离子脂质体介导的内皮抑素抑制大肠癌肝转移形成的作用。方法 建立大肠癌肝转移的动物模型 ,从静脉分别注射生理盐水 (对照Ⅰ组 )、空白质粒载体 (对照Ⅱ组 )和质粒 阳离子脂质体复合物 (治疗组 ) ,了解各组肝转移瘤情况及动物生存期。结果 治疗组动物肝转移的发生率下降和平均肝转移瘤数减少 ,其动物的生存期延长 ,肝转移瘤内的癌细胞凋亡率增高。结论 阳离子脂质体介导的内皮抑素基因静脉注射有效地控制了肝脏转移瘤的形成 ,为深入研究内皮抑素治疗大肠癌肝转移提供了新的思路。
Objective To investigate the influence of cationic liposome mediated endostatin gene on colorectal cancer liver metastasis. Methods Animal model for colorectal carcinoma liver metastasis were established. The plasmid expressing endostatin gene lipofectAMINE were injected in vein. Results After cationic liposome mediated endostatin gene were injected in vein, the incidence of liver metastasis and mean numbers of liver tumors were decreased, survival time of animal was significantly longer. Conclusion Intravenous injection of cationic liposome mediated endostatin gene can control the development of colorectal cancer liver metastasis effectively.
出处
《中国普外基础与临床杂志》
CAS
2002年第1期23-25,共3页
Chinese Journal of Bases and Clinics In General Surgery
关键词
大肠癌
肝转移
脂质体
内皮抑素
治疗
Colorectal cancer Liver metastasis Liposome Endostatin Therapy
