摘要
目的 :探讨幽门螺杆菌 (HP)的VacA和CagA抗体与胃十二指肠疾病之间的关系。方法 :采用免疫印迹法检测 2 0 0例胃十二指肠疾病患者血清中的VaCA和CagA抗体。结果 :VacA和CagA抗体在 2 0 0例患者中的检出率分别为 37.0 %、73.0 % ;在慢性胃炎 (CG)、消化性溃疡 (PU)、胃癌 (GC)患者中 ,VacA和CagA抗体的阳性率分别为 33.0 % ,31.0 % ,6 2 .5 %与 6 2 .9% ,76 .1% ,96 .9%。CG组与PU组比较 ,差异无显著性 (P <0 .0 5 ) ,GC组与CG、PU组比较 ,差异有显著性 (P >0 .0 5 )。结论 :VacA和CagA抗体在不同胃十二指肠疾病中的检出率有差异 ,但不能作为区分HP感染致不同胃十二指肠疾病的单一指标。
Objective:To investigate the relationship between anti-VacA and anti-CagA antibodies of Helicobacter pylori(HP) and gastroduodenal disease.Method:Anti-VacA and anti-CagA antibodies were tested with immunoblot.Results:The positivity rates of anti-VacA and anti-CanA antibodies were 37.0% and 73.0%; The positivity rates of anti-VacA and anti-CagA antibodies produced by HP stranis insolated from patients with chronic gastritis? peptic ulcer? gastric cancer were 33.0%?31.0%?62.5% and 62.9%?76.1%?96%.There were no significant difference in chronic gastritis and peptic ulcer. While there were significant difference in gastric cancer and chronic gastritis or peptic ulcer.Conclusions:The postivity rates of anti-VacA and anti-CagA antibodies are different in various gastroduodenal disease, but anti-CacA and anti-CagA antibodies are not reliable as a single marker for discrimination of HP pylori strains with respect to a specific gastroduodenal disease
出处
《中国现代医学杂志》
CAS
CSCD
2002年第2期53-54,共2页
China Journal of Modern Medicine
