摘要
目的:探讨胃粘膜肥大细胞(MC)与功能性消化不良(FD)之间的关系。方法:对15例健康自愿者和34例FD患者进行研究。每例胃镜下取胃窦粘膜2块,用免疫组化方法染色MC并计数。结果:34例FD患者胃粘膜MC数明显多于健康对照者(19.48/HSP±3.14/HSP与16.07/HSP±2.13/HSP,P<0.05),其中12例(35.3%)FD患者MC数超过正常人上限。且MC数与幽门螺杆菌( H.pylori)。胃粘膜炎症有明显关系。结论:FD患者胃粘膜MC数增多,可能参与了FD的发病。
Background/Aims: To investigate the relationship between gastric mast cells and functional dys- pepsia. Methods: 15 healthy volunteers and 34 patients with functional dyspepsia entered in this study. Gastric mucosal mast cells were counted after immunohistochemistry staining. H. pylon and the degree of inflammation were also investigated. Results: The number of mast cells in gastric mucosa in pa- tients with FD was greater than that in healthy volunteers(19.48 HSP±3.14/HSP vs 16.07/HSP±2.13/ HSP, P<O.05). In comparison with the controls the number of mast cells in 12 patients(35.3%) were significantly increased. There was a closed correlation between increase in mast cells, inflammation and H. pylon infection. Conclusions: The number of mast cells in patients with FD is more increased than that in healthy adults, and this may be one of the factors involved in the pathophysiology of func- tional dyspepsia.
出处
《胃肠病学》
2002年第1期27-29,共3页
Chinese Journal of Gastroenterology
