摘要
目的 :了解利培酮治疗老年期精神障碍患者的用药特点、疗效及锥体外系反应 (EPS)。 方法 :调查 5 8例以利培酮治疗 4周以上、年龄≥ 6 0岁的住院老年病人。 结果 :老年病人的平均起始剂量为 (1.2 8± 0 .6 3) m g/ d,平均治疗剂量 (2 .90± 1.2 4) m g/ d,总有效率 86 .2 % ,锥体外系反应发生率31.0 %。脑器质性精神障碍的起始和治疗剂量均低于精神分裂症 ,而疗效优于精神分裂症。晚发精神分裂症的疗效优于早发精神分裂症 ,二者的治疗剂量差异不明显。EPS的发生与剂量有关。 结论 :利培酮治疗老年期精神障碍疗效好、剂量低。
Objective:To know the application character,efficacy and extrapyramidal side effect (EPS) of risperidone in the treatment of late-life psychosis. Method:We investigated 58 case records of elderly inpatients (age≥60 years). Results:For all elderly patients,the average initial dosage was (1.28±0.63)mg/d,the average therapeutic dosage was (2.90±1.24)mg/d,the total efficacious rate was 86.2%, the incidence of EPS was 31.0%. The initial dosage and therapeutic dosage for cerebral organic mental disorder were lower than those for schizophrenia, but the efficacy of cerebral organic mental disorder were better than that of schizophrenia.The therapeutic dosage wasn't different between late-onset schizophrenia and early-onset schizophrenia. The incidence of EPS was related to dosage. Conclusion:For risperidone in treatment of late-life mental disorders,the efficacy is good,the dosage is low.
出处
《临床精神医学杂志》
2002年第1期22-23,共2页
Journal of Clinical Psychiatry
关键词
利培酮
老年期精神障碍
疗效
剂量
锥体外系反应
Risperidone
Mental disorder in late-life
Efficacy
Dosage
Extrapyramidal side effect
