摘要
目的 探讨口腔扁平苔藓(OLP)和慢性肝病的关系，从而为明确OLP的病因、诱因和发病机理提供理论和实验依据。方法 以OLP和其它口腔黏膜病患者各30例(疾病对照组)为研究对象，采用ELISA、SABC和PCR检测血清和黏膜病变区的HBV表达。结果 OLP组检测到血清中HBsAg阳性者11例(36.7%)，疾病对照组中仅检测到1例，(3.3%)(P＜0.05)；SABC检测到8例OLP口腔黏膜病变区上皮细胞HBsAg阳性，疾病对照组检测到1例(P＜0.05)；PCR检测到OLP组HBV DNA阳性者2例，疾病对照组1例，两者相比无显著性差异。结论 OLP与HBV感染是有关系的，OLP的发病机制可能是一种循环免疫复合物的作用。
Objective To assess the association between oral lichen planus(OLP) and chronic active hepatitis(CAH),and provide useful data for disclosing the pathogenic mechanisms of OLP.Methods 30 cases of OLP were recruited into the study,30 cases with other oral mucous membrane diseases and 18 cases with normal oral mucous as control groups.We use ELISA to detect HBV markers in the serum samples,and use SABC and PCR technique to locate HBsAg and determine HBV DNA in the oral mucous membrane of OLP.Results 11 patients with OLP(36.7%) and 1 control(3.3%) were found to be with HBV markers(P<0.05),we can see brown HBsAg granules scattering the epithelial cytoplasm. Furthermore, HBV DNA were found between OLP and control group. Conclusion OLP may be associated with HBV infection ,it is suggested that immunity complex(IC) play an important role in the pathogenesis of OLP.
出处
《临床口腔医学杂志》
2001年第3期219-220,共2页
Journal of Clinical Stomatology
