摘要
目的：了解ＯＬＰ患者ＨＣＶ感染情况，探讨ＨＣＶ感染与ＯＬＰ之间的关系。方法：用全自动生化检测仪，酶联免疫测定及ＰＣＲ法分别测定４１名ＯＬＰ患者和３８名对照者外周血ＳＧＰＴ、ＳＧＯＴ、抗－ＨＣＶ和ＨＣＶ－ＲＮＡ。结果：４１名ＯＬＰ患者中，１５人（３６．６％）有肝酶异常升高、１２人（２９．３％）抗－ＨＣＶ阳性，１０人（２４．４％）ＨＣＶ－ＲＮＡ阳性；而３８名对照组中，６人（１５．８％）有肝酶异常升高，３人（７．９％）抗－ＨＣＶ阳性，３人（７．９％）ＨＣＶ－ＲＮＡ阳性，ＯＬＰ组的上述三项指标均较对照组为高（Ｐ＜０．０５、Ｐ＜０．０１、Ｐ＜０．０５），两组存在明显的差异。结论：国人ＯＬＰ患者存在较高的ＨＣＶ感染率，表明有相当部份的ＯＬＰ患者体内有ＨＣＶ存在与复制，ＯＬＰ的发病可能与此有一定的关系。
Objective:To investigate the infectious condition of hepatitis C virus (HCV) in the patients with oral lichen planus (OLP) and to study the relationship between OLP and HCV infection.Methods:The SGPT,SGOT,anti HCV antibodies and HCV RNA in the serum samples of the 41 OLP patients and 38 controls were examined respectively by the auto biochemical assay,enzyme immunoassay (EIA) and polymerase chain reaction(PCR).Results:In the 41 OLP patients and 38 controls,15(36.6%) patients and 6(15.8%) controls had abnormal liver transaminase level ( P <0.05);12(29.3%) and 3 (7.9%) positve anti HCV antibodies ( P <0.01);10(24.4%)and 3(7.9%)positive HCV RNA( P <0.05);Conclusion:OLP patients have a high HCV infection rate.OLP might be related to the existence and reproduction of HCV to a certain extent.
出处
《实用口腔医学杂志》
CAS
CSCD
北大核心
1999年第2期112-114,共3页
Journal of Practical Stomatology
关键词
口腔粘膜疾病
扁平苔藓
丙型肝炎病毒
感染
Lichen planus
Hepatitis C virus
Viral RNA
Polymerase chain reaction
Liver function tests
