摘要
目的 比较胰岛素泵 (CSII)和多次皮下注射胰岛素 (MSII)治疗老年 2型糖尿病患者高血糖的疗效。 方法 CSII组与MSII组患者各 30例 ,均进行胰岛素强化治疗。治疗前CSII组空腹血糖显著高于MSII组。 结果 治疗后CSII组空腹血糖、3餐后 2h平均血糖 (APBG)和睡前血糖〔(6 6± 1 2 )、(8 5± 1 5 )和 (7 0± 1 9)mmol/L〕均较MSII组〔(8 8± 2 1)、(9 6± 2 2 )和 (8 6± 2 2 )mmol/L〕下降显著 (P <0 0 5或P <0 0 1) ,达到了预期强化控制水平。CSII组空腹血糖达标率(86 7% )显著高于MSII组 (2 3 3% ,P <0 0 1) ,两组餐后血糖达标率以及低血糖发生率差异无显著性。CSII组比MSII组少用胰岛素约 15 %。 结论 控制餐后高血糖 2种方法同样有效 ,但CSII控制血糖 ,尤其是对空腹高血糖更迅速有效。
Objective To compare the effects of continuous subcutaneous insulin injection(CSII) and multiple subcutaneous insulin injection(MSII) on hyperglycemia in 60 elderly patients(30 in each group). Methods For the baseline parameters including HbA1c, fasting blood glucose(BG), average BG at the second hour of three postprandial (APBG) and bedtime BGs, only fasting BG level in CSII group was markedly higher than that in MSII group. Results On the third day of post insulin therapy for two groups(CSII vs MSII), the fasting BG 〔(6 6±1 2) vs (8 8±2 1)mmol/L, P <0.01〕, APBG〔(8 5±1 5) vs (9 6±2 2)mmol/L, P <0 05〕 , the bedtime BG 〔(7 0±1 9) vs (8 6±2 2)mmol/L, P <0 05〕, and the control rate of fasting BG(86 7% vs 23 3%, P <0 01) were significantly different, but control rate of postprandial BGs and hypoglycemia incidence between two groups showed no significant changes. Conclusions Both CSII and MSII could almost equally control the postprandial BGs, but CSII alleviated the hyperglycemia, especially for fasting BGs, much faster and more effectively than MSII.
出处
《中华老年医学杂志》
CAS
CSCD
北大核心
2001年第5期334-336,共3页
Chinese Journal of Geriatrics
