摘要
目的探讨肺癌合并胸水的综合治疗方法。方法 :对 5 6例肺癌合并胸水患者施行胸膜全肺切除并于开胸前静推顺铂 6 0～ 80mg和环鳞酰胺 80 0～ 10 0 0mg ,术毕关胸前用 4 3～ 4 5℃的蒸馏水浸泡胸腔 30～ 4 5min ,然后用含抗癌药物的生理盐水反复冲洗 ,术后 3d每日静点鬼臼乙叉甙 10 0mg。 1月后开始化疗或放疗。结果 :全组病人术后均控制了胸水和呼吸道症状 ,手术并发症 6例 ,无手术死亡。 1,2 ,3年生存率分别为 89.3% ,5 8.3% ,2 4 .4 %。结论 :胸膜全肺切除配合围手术期化疗和热疗能有效地控制肺癌合并胸水的临床症状 ,减少局部复发 ,延长患者生命。但对预防远期转移尚不满意。
Objective:To explore combined therapy of lung cancer complicated with pleural fluid.Method:Fifty_six cases of lung cancer complicated with pleural fluid underwent pleuropneumonectomy.60 to 80 mg ciplatin and 800 to 1000mg cyclophosphamide were intravenously injected before thoracotomy.Thoracic cavity was soaked in distilled water for 30 to 45 minutes and was flushed with solution of anticarcinogen in physiological saline.In the three days after operation,100mg Etoposide were intravenously dripped per diem.Chemotherapy and Radiotherapy were exerted one month after operation.Results:Pleural fluid and airway symptoms were all controlled in this group.The surgical complication occurred in 6 patients,and there was no surgical mortality.One_year,Two_year and Three_year survival rate was 89.3%,58.3%,24.4% respectively.Conclusions:Pleuropneumonectomy associated with perioperative chemotherapy and themotherapy can control the clinical symptoms of lung cancer complicated with pleural fluid,reduce local relapse and prolong patients' life.But it is not satisfied for the prevention from metastasis.
出处
《中国现代医学杂志》
CAS
CSCD
2002年第3期45-46,49,共3页
China Journal of Modern Medicine
