摘要
目的：探讨迷走神经刺激术（ＶＮＳ）抗癫痫作用的机制是否为ＶＮＳ引起孤束核部位ＧＡＢＡ含量变化。方法：通过Ｗａｔｅｒｓ高效液相色谱系统分析３２只接受不同持续时间迷走神经刺激的大鼠脑干孤束核部位，主要兴奋及抑制性氨基酸含量的变化。结果：１小时持续刺激组孤束核部位ＧＡＢＡ含量，较对照组升高且差异有显著意义。结论：迷走神经刺激术可能通过升高孤束核部位的ＧＡＢＡ含量起到抗癫痫作用。
Objective: To demonstrate the hyposis that the possible mechanism of the anticonvul- sant effect of vagus nerve stimulation (VNS)is the increase of GABA release at the nucleus of solitary tract(NTS). Methods: 32 Wistar rats was divided in to 4 groups, all the rats were operated to expose the left vagus nerve and attach it to the electrodes, after O, O. 5, 60 minute continuous stimulation, and 60 minutes intermittent stimulation (2ms pulse width, 100HZ, 10V), amino acid level in the tissue from brainstem (tractus solitarius) was analasysed. result: In one hour continuous stimulation group GABA level is increased(P < 0. 05 ). There was no alteration of other amino acid level. Conclusion: Our results suport the hyposis that the possible mechanism of the antiepileptic action of the VNS is vagus nerve causes GABA released at NTS.
出处
《立体定向和功能性神经外科杂志》
2001年第4期199-201,共3页
Chinese Journal of Stereotactic and Functional Neurosurgery
