摘要
目的：探讨多囊卵巢综合征（ＰＣＯＳ）病人高胰岛素和高黄体生成素血症在其高雄激素血症中可能的作用。方法：放免法测定了１１８例ＰＣＯＳ病人空腹血清中胰岛素（ＩＮＳ）、黄体生成素（ＬＨ）、卵泡刺激素（ＦＳＨ）、泌乳素（ＰＲＬ）、雄烯二酮（Ａ）、睾酮（Ｔ）和雌二醇（Ｅ２）。对ＩＮＳ和ＬＨ值与各激素的相关关系进行了分析；将病人按ＩＮＳ水平高低分为三组，分析各组间雄激素及ＬＨ和ＬＨ／ＦＳＨ值的分布情况；按体重指数将病人分肥胖和非肥胖组，组间各激素值进行了比较。结果：ＩＮＳ与Ａ和Ｔ均明显正相关；胰岛素偏低组中ＬＨ与Ａ和Ｔ明显正相关，而胰岛素偏高组中ＬＨ与Ａ和Ｔ无相关性；ＩＮＳ与ＬＨ和ＬＨ／ＦＳＨ无相关性；肥胖组的ＬＨ／ＦＳＨ均值明显低于非肥胖组；雄激素偏高组中ＩＮＳ和ＬＨ均增高。结论：ＰＣＯＳ病人的高ＩＮＳ和高ＬＨ血症可能共同存在，协同作用下导致其高雄激素血症。
Objective: To investigate the role of hyperinsulinemia and high luteinizing hormone (LH) level in the hyperandrogenism of patients with polycystic ovary syndrome (PCOS). Methods: We measured serum insulin. LH. follicle stimulating hormone (FSH). prolactin (PRL). androstenedione (A). testosterone (T) and e- strodials(E2) by RIA. Correlativity of insulin and LH value with other hormone is estimated. Patients were divided into three groups by insulin levels, and LH.LH/FSH.A and P values were compared between the groups. Hormone levels were compared between obese and non-obese groups divided by RML Results: Insulin were possitivly correlative with both A and T values. In higher insulin level group. LH and LH/FSH were not correlative to both A and T. But in lower level insulin group, LH and LH/FSH. were possitivly correlative to A and, LH was correlative with T but LH/FSH. Insulin was not correlative to both LH and LH/FSH. LH/FSH value in obese group was lower than non-obese group. Both insulin and LH were increased significantly in high androgen group. Conclusion: There maybe both hyperinsulinemia and high LH level in PCOS. It's insulin and LH synergism leads to hyperandrogenism.
出处
《海军总医院学报》
2001年第3期132-135,共4页
Journal of Naval General Hospital of PLA
