摘要
目的 :探讨脾大部分栓塞治疗对肝硬化肝功能失代偿期患者免疫功能影响。方法 :检测肝硬化肝功能失代偿期患者脾大部分栓塞治疗前后 ,外周血T细胞亚群百分率及血清可溶性白细胞介素 2受体水平变化 ,并与健康人对照。结果 :肝硬化患者脾大部分栓塞前外周血CD+ 3 、CD+ 4百分率 ,CD+ 4/CD+ 8细胞比值均明显低于健康人 ,差异有统计学意义 ;栓塞治疗 8周后 ,均有不同程度上升 ,但仍低于健康人 (P <0 .0 5 ) ;而CD+ 8细胞百分率、血清可溶性白细胞介素 2受体水平在栓塞前均显著高于健康人 (前者P <0 .0 5 ,后者P <0 .0 1) ,栓塞后两者均下降 ,与健康人相比 ,前者P >0 .0 5 ,后者P <0 .0 5。结论 :巨脾可能是肝硬化功能失代偿期患者免疫功能异常的重要原因之一 ,脾大部分栓塞可部分改善患者的免疫功能 ,有重大临床意义。
Objective:To explore the changes and its clinical significance of immunologic function in cirrhosis patients with portal hypertension treated by spleen arterial embolization therapy.Methods:The proportion of T lymphocyte subsets were assayed by indirect immunofluorescence,and ELISA was used to measure the levels of soluble interleukin-2 reception.A comparative analysis was carried out between the patients before or after therapy and the control group.Results:The proportion of CD3 +,CD4 + T cell and the ratio of CD4 +/CD8 + in peripheral bloods were significantly lower in patients before the treatment than those in cotrol group (P<0.01).Eight weeks later after spleen arterial embolization,they all went up to different degree,but sitll were lower than those in control group.The proportion of CD8 + T cell and the concentration of soluble interleukin-2 receptions in serum were higher in patients before therapy than those in control group (P<0.05),and they were decreased remarkably after the treatment.Compared with that in control group,the difference in the proportion of CD8 + T cell was not statistically significant (P>0.05).Conclusions:Huge spleen may be one of the important causes of immunologic function abnormality in cirrhosis with portal hypertension, and spleen arterial embolization can ameliorate partly patients' immunologic function.
出处
《中国现代医学杂志》
CAS
CSCD
2001年第11期4-5,共2页
China Journal of Modern Medicine
关键词
肝硬化
脾栓塞
T细胞亚群
可溶性白细胞介素2受体
Cirrhosis
Spleen Arterial Embolization
T Lymphocyte Subsets
Soluble Interleukin-2 Reception
