摘要
内皮素(ET)是新近分离出的一种血管活性多肽,在体内外均有强烈的缩血管作用。本文通过对麻醉大鼠一次静注ET,观察其对大鼠血压和肾功能的影响。结果发现静注ET使大鼠血压出现先降后升的双相反应,肾小球滤过率、尿量、肾脏钠和钾排泄明显下降,但钠排泄分数在实验期间无明显变化。
Endothelin (ET) is a recently discovered vasoaotive peptide. It has been shown to have potent vasoconstriotive effects in vivo and in vitro. The present study in anaesthetized rats was to investigate the effects of ET on blood pressure and renal function including glomerular filtration rate (GFR), urine flow (UV), renal sodium excretion (UNa+V), renal potassium excretion (UK+V) and fractional sodium excretion (FENa+) by intravenous bolus injection of ET. Results showed that ET caused a biphasic arterial blood pressure response with a marked lowering at the every start, and a rapid elevation later. It also caused significant decrement in GFR (P<0.001), UV(P<0.001), UNa+·V(P<0.05) and UK+·V(P<0.01). FENa+ was not significantly changed during the test. The findings cited above indicate that ET has a marked pressor effect, accompanied by a significant decrease in GFR and renal electrolyte excretion.
出处
《上海医科大学学报》
CSCD
1991年第2期115-118,共4页
Journal of Fudan University(Medical Science)
关键词
内皮素
血压
肾功能
endothelin
blood pressure
renal function
rat
