摘要
敌桔双对实验动物(大鼠、小鼠和猴)有致畸作用,并有明显的剂量-反应关系和种属差异,对大鼠是强致畸物(TD_(50)为2.18mg/kg)。毒物动力学研究也提示这一点。敌枯双可抑制实验动物胚胎组织DNA和RNA合成,以及抑制人胚上腭间质细胞生长(IC_(50)为1.32×10~6mol/L)。在理论上对人有潜在的致畸。两次人群流行病学调查,均未揭示使用敌枯双地区不良妊娠结局发生率有明显增加;对生产敌枯双女工妊娠结局健康调查,也未表明敌枯双对人有明显的致畸作用。居民食用喷药3次或1次后,稻米的接触日剂量为大鼠致畸阈剂量(TD_(01)为0.22mg/kg)的1/367和1/4400。在目前还未找到有效的农药取代敌枯双情况下,在切实加强危险度管理的基础上,敌枯双可以作为农药使用。
MATDA [N, N'-Methylene-bis-(2-amino-1, 3, 4-thiadiazole)] is a teratogen of experimental animals (rat, mouse and rhesus monkey). There existed dose-response relationship and great differences between species, especial for rat, more sensitive to teratogenio effect of MATDA (TD50=2.18mg/kg). The toxicokinetic fate of MATDA in animals showed species differences. MATDA inhibited the DNA and RNA syntheses in embryonic tissues of experimental animals and inhibited the growth of the human embryonic palate mesenohymal cells (IC50=1.32× 10-6mol/L). In theory, the teratogenio potential of MATDA may exist in human. However, two of the large-scale epidemiological studies did not revealed that the occurences of adverse pregnancy outcomes increased in area in which MATDA is applied for agricultural use. The survey of pregnancy outcomes of female workers exposed to MATDA is not showed that MATDA is teratogenio in human. The exposure levels (the daily dose) of residents consumed rice to be applied 3 and 1 times with MATDA were 1/367 and 1/4 400 of the threshold teratogenic dose for rat (TD01=0.22mg/kg), respectively. Taken into considerati n that no effective pesticide displace MATDA at present, MATDA can be used as pestioide under strict management of risk.
出处
《上海医科大学学报》
CSCD
1991年第1期41-47,共7页
Journal of Fudan University(Medical Science)
基金
国家自然科学基金资助
关键词
农药
敌枯双
致畸作用
敌枯唑
N, N'-Methylene-bis-(2-amino-1, 3, 4-thiadiazole)
2-Amino-1, 3, 4-thiadiazole
teratogen
riee bacterial blight
