摘要
采用 HPL C测定血清中盐酸曲马多的浓度 ,研究了 12名健康志愿者单剂量和多剂量交叉口服两种盐酸曲马多缓释片的相对生物利用度 ,经统计学分析 ,两制剂各药物动力学参数均无显著性差异 。
A HPLC method was used for determination of tramadol hydrochloride in human serum. The relative bioavailability of two brands of tramadol hydrochloride sustained release tablets was studied in healthy volunteers. The results showed there was no statistically significant difference for pharmacokinetic parameters between the two bioequivalent preparations.
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
2001年第10期457-459,共3页
Chinese Journal of Pharmaceuticals
关键词
盐酸曲马多
缓释片
生物利用度
药物动力学
HPLC
tramadol hydrochloride
sustained release tablets
bioavailability
pharmacokinetics
HPLC
