摘要
目的 探讨在体外受精 胚胎移植 (IVF ET)周期中血清及卵泡液中血管内皮生长因子(VEGF)水平的变化 ,及其在预测卵巢过度刺激综合征 (OHSS)中的作用。方法 收集 42例行IVF ET患者的血清和卵泡液标本 ,采用定量酶联免疫方法检测血清、卵泡液中VEGF水平 ,按是否发生OHSS分为OHSS组 (10例 )及对照组 (32例 ) ,对两组临床资料、性激素和VEGF水平进行回顾性相关分析。结果 OHSS组血清VEGF水平在月经周期的各个时期均高于对照组 ,但差异无显著性 (P >0 0 5 )。OHSS组卵泡液VEGF水平为 (1487 7± 36 5 8)ng/L ,较对照组的 (10 2 5 8± 474 7)ng/L明显升高 ;取卵时卵泡数目增多 ,OHSS组为 (10 0± 5 9)个 ,对照组为 (6 1± 2 3)个 ;基础黄体生成素 (LH) ,人绒毛膜促性腺激素 (hCG)、注射日雌二醇 (E2 )水平均比对照组高 ,差异有显著性 (P <0 0 5 )。结论 OHSS组卵泡液VEGF水平明显高于对照组 ,提示VEGF可能参与了OHSS的发病 ;卵泡液VEGF水平可以作为预测OHSS发生的检测指标。
Objective To evaluate the function of vascular endothelial growth factor (VEGF) and other clinical indexes to forcast ovarian hyperstimulation syndrome (OHSS). Method Collecting the serum and follicular fluid (FF) of 42 cases in the in vitro fertilization and embryo transfer (IVF-ET) cycles and then analysis the relationship of the clinical and detected indexes between the OHSS (10 cases) and the non-OHSS (32 cases). Results The concentration of VEGF in FF?E 2 on the day of human chorionic gonadotropin (hCG) injection, basal luteinizing hormone (LH) and the number of ovum retried much higher in the OHSS than in the non-OHSS. Conclusions The concentration of VEGF in FF of OHSS cases is higher than that of controls, supporting the role of VEGF as a mediator of OHSS. Therefore VEGF in FF is a forcast index of OHSS.
出处
《中华妇产科杂志》
CAS
CSCD
北大核心
2001年第11期651-653,共3页
Chinese Journal of Obstetrics and Gynecology
关键词
淋巴因子
血管内皮生长因子
卵巢过度刺激综合征
酶联免疫吸附测定
医源性疾病
超促排卵
Lymphokines
Endothelial growth factors
Ovarian hyperstimulation syndrome
Fertilization in vitro
Embryo transfer
Enzyme-linked immunosorbant assay
