1Ferrara N,Henzel WJ.Pituitary follicular cells secerte a novel heparin-binding grawth factor specific vascular endothelial cells.Biochem eio-phys Res Commun,1989,161(2):851
2Neufeld G,Cohen T,Stela G,et al.Vascular en-dothelial growth factor(VEGF) and its receptors.FASEB J,1999,13:9-22
3Tischer E,Mitchell R,Hartman T,et al.The human gene for vas-cular endothelial growth factor:Multiple protein foms owe encoded through altemative exou splicing[J].J Biol chem,1991,266:11947-11954
4Ferrara N.The bilolgy of vascular endothelial growth factor.En-docr Rev,1997,18:4
5Mustonen T.Endothelial receptor tyrosine kinase involved in a-ngioenesis.J cell Biol,1995,129:895
6Fong GH,Rossant J,Gertsensteiu M,et al.Role of the Flt-Ireceptor ty-rosine kinase in regulation the assembly of vasular endothelium.Nature,1995,376:66-70
7Lazarour DF,Shou M,Scheinouitz M,et al.Comparative effects of basic fi-broblast growth factor and vascular enothelial growth factor on coronary col-lateral development and the arferial response to injury.Circulation,1996,94:1074-1087
8Murohara T,Horowitz JR,Silverm M.Vascular en-dothelial growth factor/VPE enhances vascular permeability via nitric oxide and prostacyclin.Cir-culation,1998,97:99-107
9Schaper w,lto WD.Molecular mechanistns of coronory collateral vessel growth.Civc Res,1996,79:911
10Banai s,Jaklitsh MT,shou M,et al.Angiogenic induced en-hancement of collatral blood flow to ischemic myocardium by vascular endothelial grouth factor in dogs.circulation,1994,89:2183
4The Group of Chronic Obstructive Pulmonary Disease (COPD). Respiratory Society, Chinese Medical Association. Guidelines for the diagnosis and therapy of COPD (2007)[J]. Chinese Journal of Tuberculosis and Respiratory Diseases, 2007, 30:8-17.
5Doi M,Nakano K,Hiramoto T,et al.Signifieance of pulmonary artery pressure in emphysema patients with mild-to-moderate hypoxemia.Respir Med, 2003,97 : 915-920.
6Howe HK,Preston RJ,Meloughlin P. Chronic hypoxia causes angiogenesis in addition to remodeling in the adult rat pulmonary cireulation [J].J Physiol,2003,547(1):133-145.
7Mitani Y, Maruyama K, Sakurai M. Prolonged administration- Arginine ameliorates chronic pulmonary hypertension and pulmonary vascular remodeling in rats [J]. Circulation,1997,96: 689-697.
8Carratu P,Seoditti C,Maniscalco M,et al.Exhaled and arterial levels of endothelin-1 are increased and correlate with pulmonary systolic pressure in COPD with pulmonary hypertension.BMC Pulm Med, 2008,8:20.
9Keveur A, Callehert J,Herve P,et al.High plasma serotonin levels in primary puhnonary hypertension. Arte rioseler Thronab Vasc Biol, 2000,20:2233-2239.
10Moudgil R,Michelakis ED, Archer SL. The role of K+ channels in detemining puhnonary vascular tone, oxygen sensing, cell proliferation and apoptosis: Implications in hypoxic pulmonary vasoconstriction and pulmonary arterial hypertension [J]. Microcirculation, 2006,13(8):615-632.
