摘要
目的探讨p21WAF1基因与肝细胞癌(HCC)临床病理特征(组织学分级、转移、肿块大小和包膜形成)的相关性。方法随机选择45例肝细胞癌患者的癌和癌旁肝组织标本,SP法检测其p21WAF1蛋白表达,分析p21WAF1基因与HCC临床病理特征(组织学分级、转移、肿块大小和包膜形成)的相关性。结果p21WAF1在癌和癌旁肝组织中阳性表达率分别为68.9%和15.6%,两者比较,差异有统计学意义(P<0.01);HCC组织学分级、有无转移、肿块大小、有无包膜形成者p21WAF1蛋白阳性表达率比较,差异均无统计学意义(P>0.05)。结论p21WAF1基因表达阳性率在HCC的临床病理特征(组织学分级、转移、肿块大小和包膜形成)间无差异,p21WAF1尚不能作为HCC分化不良及预后的指标。
Objective To study the correlation of expression of p21WAF1 gene with the clinical pathological features （histological grade, metastasis and tumor size or cover producing） of hepatocellular carcinoma （HCC）. Methods The cancer tissue and peri -cancer tissue samples of the 45 patients with HCC were as random taken. P21WAF1 protein expression in the samples was detected by the immunieytochemical method （SP）. The correlation of expression of p21WAF1 gene with the clinical pathological feature （histological grade, metastasis and tumor size or cover producing） of HCC was studied. Results The positive expression rates of p21WAF1 proteins in the cancer tissue and peri - cancer tissue samples were respectively 68.9% and 15.6%, with a significant difference （ P 〈0. 01 ）. But no correlation was found between expression of p21WAF1 protein expression and clinical pathological features （ histological grade, metastasis and tumor size or cover producing） of HCC （ P 〉 0.05）. Conclusion The positive expression of p21WAF1 gene is not directly correlated with the clinical pathological features （ histological grade, metastasis and tumor size or cover producing） of HCC. So p21WAF1 could not serve as an index for malignant differentiation and prognosis of HCC.
出处
《中国全科医学》
CAS
CSCD
2008年第1期26-27,共2页
Chinese General Practice
基金
美国军事医学与材料管理科研基金(BC010046&BC033154)
中国国家自然科学基金会科研基金(39925037)
