摘要
【目的】探讨应用晶状体上皮细胞清除的方法预防后囊混浊。【方法】应用新西兰白兔 10只 ,将 2 0眼随机分 2组 ,分别为对照组和胰蛋白酶组。晶状体囊袋内超声乳化吸出晶状体皮质 ,保留完整囊袋 ,胰蛋白酶组向囊袋内注入 2 5 g/L胰蛋白酶保留 1min ,冲洗清除晶状体上皮细胞 ,最后撕去前囊。对照组将胰蛋白酶换为平衡盐水 ,其他方法相同 ,术后观察后囊混浊的发生情况。【结果】术后 4周 ,胰蛋白酶处理组 8眼晶状体囊保持透明 ,后囊无混浊 ,2眼轻度混浊。对照组 10眼均有不同程度的后囊混浊。两组后囊混浊情况经统计学处理有显著差异 (P <0 0 1)。【结论】应用胰蛋白酶清除晶状体上皮细胞可以显著预防后囊混浊的发生。
To investigate the prevention of posterior capsule opacification by clearance of lens epithelial cell. Ten New Zealand rabbits were used for experiment. Twenty eyes were divided into two groups. One is trypsin treated group, the other is control group. Endocapsular phacoemulsification was performed, lens cortex was extracted. The capsular bag was filled by 2 5 g/L of trypsin in trypsin treated group. About one minute after the injection, the lens epithelial cells were removed by irrigation/aspiration. The anterior capsule was removed at last. Trypsin was replaced by balance salt solution in control group. Other procedures were the same with trypsin treated group. Posterior capsule opacification was observed for 4 weeks. The lens posterior capsules of 8 eyes were clear 4 weeks after operation in trypsin treated group, mild opacification was observed in 2 eyes. Posterior capsule opacification was found in all eyes in control group. There was statistically significant difference between the two groups(P<0 01). [Conclusion] Posterior capsule opacification can be prevented by removing of lens epithelial cells with trypsin.
出处
《中山医科大学学报》
CSCD
北大核心
2001年第6期447-450,共4页
Academic Journal of Sun Yat-sen University of Medical Sciences
基金
广东省重点科技攻关项目 ( 2KM 0 5 2 0 4S)
关键词
胰蛋白酶
晶状体
上皮细胞
后囊混浊
trypsin
lens
epithelial cells
posterior capsule opacification
