摘要
目的 分析未分化型鼻咽癌的治疗效果及预后因素。方法 对 1990～ 2 0 0 0年收治的149例病理类型为未分化型的鼻咽癌患者的临床资料进行了回顾性分析 ,按 1992年福州鼻咽癌学术会议制定的分期标准分期 ,Ⅰ期 4例 ,Ⅱ期 33例 ,Ⅲ期 73例 ,Ⅳ 39例。治疗方案 :单纯放疗 78例 ,诱导化学药物治疗 (化疗 )加放疗 32例 ,同步化疗加放疗 39例。结果 未分化型鼻咽癌占鼻咽癌总数的 3 5 8%。 149例患者的 5年总生存率为 6 4 48% ,无瘤生存率为 6 0 35 % ,无远处转移生存率为77 0 5 % ,无局部区域复发生存率为 80 13%。影响预后的主要因素为N分期及TNM分期。结论 未分化型鼻咽癌是鼻咽癌中的一种少见型 ,N分期及TNM分期为影响预后的主要因素 ,以放疗为主的治疗方案 ,对未分型鼻咽癌有较好的疗效。
Objective To study the therapeutic effect and prognosis of undifferentiated nasopharyngeal carcinoma. Methods 149 patients with undifferentiated nasopharyngeal carcinoma, 4 at stage I, 33 at stage II, 73 at stage III, and 39 at stage IV according to the Fuzhou Staging Criteria of Nasopharyngeal Carcinoma 1992, were treated mainly by radiotherapy from 1999 to 2000: 78 of them underwent radiotherapy alone, 32 underwent radiotherapy combined with induced chemotherapy, and 39 underwent radiotherapy combined with synchronized chemotherapy. Relevant clinical data, especially the therapeutic effect upon and prognosis of the type, were analyzed. Results Undifferentaited nasopharyngeal carcinoma accounts for 3.58% of nasopharyngeal carcinoma and was with a 5 year overall survival rate (OS) of 64.48%, a disease free survival rate (DFS) of 60.35%, a distance metastasis free (DMF) survival rate of 77.05%, and a local recurrence free(LRF) survival rate of 80 13%.The key factors influencing prognosis were the stage of N and stage of international classification of cancer based on TNM. Conclusion Undifferentiated nasopharyngeal carcinoma is a rare type. Its prognosis is influenced mainly by the stage of N and TNM. Treatment maninly on radiotherapy is effective.
出处
《中华医学杂志》
CAS
CSCD
北大核心
2001年第24期1488-1489,共2页
National Medical Journal of China
