摘要
目的:观察新辅助化疗对Ⅱ、Ⅲ期鼻咽癌的近期疗效及生存率的影响。方法:69例初治NPC病人随机分组,观察组给予DDP+CF/5-FU化疗三个疗程后常规放疗,对照组给予常规放疗。结果:观察组CR率96%,总有效率(CR+PR)100%,2年无病生存率90%,2年总生存率92%;对照组CR61.8%,总有效率91.2%,2年无病生存率69%,2年总生存率73%。经统计学处理,两组CR率有显著性差异(P<0.01),总有效率无显著性差异(P>0.05),2年无病生存率及总生存率有显著性差异(P<0.01)。结论:新辅助化疗对提高Ⅱ、Ⅲ期鼻咽癌的近期疗效及生存率具有临床意义。
Objective: To evaluate the influence of new adjuvant chemotherapy on short term efficacy, surival rate, and survival time of the nasopharyngeal cancers(NPC) patients in stage Ⅱ and stage Ⅲ. Methods: The patients were randomly assigned into two gronps: the testing group was treated with regiment of DDP+CF/5 FU for three courses and followed by convene Ronal radiotherapy, the control group was given routine radiotherapy. Results: The testing group achieved complete response(CR)of 96%,all response rate of 100%,2 year disease free survival rate of 90%,while control group achieved complete response of 61.8%, all response rate of 91.2%, 2 year disease free survival rate of 69%.There was significant difference between the two groups in CR, 2 year survival rate, and 2 year disease free survival rate(P< 0.01). However,there was no difference in all response rate. Conclusion: This new adjuvant chemotherapy can significantly improve short term efficacy and survival rate of the NPC patients in stage Ⅱ.
出处
《癌症》
SCIE
CAS
CSCD
北大核心
2001年第12期1403-1404,共2页
Chinese Journal of Cancer
关键词
鼻咽肿瘤
新辅助化疗
放射疗法
生存率
Nasopharyngeal cancer
New adjuvant chemotherapy
Radiotherapy
Survival rate
