摘要
目的 观察P(Paclitaxel ,PTX)P(DDP)方案诱导化疗联合放疗对晚期鼻咽癌的治疗效果。方法 观察组 40例鼻咽癌患者给予PP方案 (PTX 15 0mg/m2 d1,DDP 10 0mg/m2 d2 ) ,化疗 2～ 3周期后常规放疗 (鼻咽 66～ 74Gy ,颈部淋巴结 62～ 70Gy ,颈部淋巴结预防量44～ 5 0Gy) ,对照组 46例给予常规放疗。结果 观察组总有效率为 72 5 % ,对照组为 5 0 0 % ,有显著差异 (P <0 0 5 ) ;3年生存率分别为 5 7 9% ,43 5 % (P <0 0 5 ) ;3年局部控制率分别为 71 1% ,5 6 5 % (P <0 0 5 ) ;3年远处转移率分别为 2 1 1% ,3 9 1% (P <0 0 5 )。结论 PP方案可用于鼻咽癌诱导化疗 ,增加放疗敏感性 ,提高 3年生存率及局部控制率 ,降低了远处转移率。
Objective To study the influence of program PP inducement chemotherapy associated with radiotherapy in the treatment of advanced nasopharyngeal carcinoma patients.Methods The testing group was treated with Paclitaxel+DDP(PTX 150 mg/m 2 d 1,DDP 100 mg/m 2 d 2)for 2～3 courses then followed by normal radiotherapy(primary tumor with 66～74Gy,involved areas of the neck with 62～70Gy,the univolved areas with 44～50Gy),the control group was given the same radiotherapy alone.Result The testing group achieved all response rate 72.5%,while the control group only 50.5%,There was significant difference between the two groups (P<0.05),The 3-year survival rates of the two groups were 57.9%、43.5% (P<0.05),The 3-year control rates and distant metastasis rates of the two groups were 71.1%、56.5% and 21.1%、39.1%(P<0.05).Conclusions PTX+DDP could be used in the inducement chemotherapy of nasopharyngeal carcinoma.
出处
《河南肿瘤学杂志》
2004年第5期338-339,共2页
Henan Journal of Oncology
关键词
紫杉醇
顺铂
鼻咽肿瘤
诱导化疗
放射治疗
Paclitaxel
DDP
nasopharyngeal carcinoma
chemotherapy
radiotherapy
