摘要
目的探讨绝经后骨质疏松有效的预防措施。方法采用激素替代治疗(HRT)中的连续联合治疗方案,每日服用倍美安1片,连续半年,测定服药前后的血碱性磷酸酶(ALP)、骨钙素(BGP)、空腹尿钙/肌酐(Ca/Cr)、骨矿含量(BMC)、雌酮(E1)、雌二醇(E2)、睾酮(T)。结果与服药前相比较,ALP、BGP、Ca/Cr有显著性下降,以Ca/Cr下降最为显著,BMC维持不变,对照组的BMC下降4.9%。结论HRT对骨形成和骨吸收均有抑制作用,但以抑制骨吸收为主,从而防止骨丢失,保持骨量,预防骨质疏松。
Objective To explore efficient method to prevent postmenopausal osteoporosis.Method The women took hormone replace therapy (HRT) for six months. The difference of blood alkaline phosphatase (ALP), bone gla protein(BGP),urine gla/creatine(Ca/Cr), bone mineral content (BMC), estrone(E1), estradiol(E2) and testosterone (T) before and after taking the drug were analysed.Result After taking the drug for six months, ALP,BGP,Ca/Cr descreased differencitly.BMC maintained.The BMC of the contrastant group descreased 4.9%.Conclusion The HRT restrained bone absorption and bone forming.The bone absorption was resteained outstandly.The scheme of continuous uniting could prevent postmenopausal osteoporosis (PMO).
出处
《中国临床康复》
CSCD
2002年第1期84-85,共2页
Chinese Journal of Clinical Rehabilitation
