摘要
目的：探讨丹参酮Ⅱ Ａ（ＴａｎⅡＡ）对大鼠出血性休克－再灌注肾损伤的防治作用。方法：ＳＤ大鼠 ３０只，分ＴａｎⅡＡ高、中、低剂量组、ＰＥＧ组和复苏２４ｈ组，每组６只。采用修改的Ｙｕ’ｓ法制备本实验模型，观察腹腔注射ＴｎⅡＡ后的肾组织病理形态学改变和树突状细胞（ＤＣ）的分布特点，并与复苏组比较。结果：ＴａｎⅡＡ能减轻肾组织损伤，降低间质ＤＣ的免疫活性，二者呈正相关；而且与对照组、复苏 ２４ ｈ组比较均有显著性差异（Ｐ＜０．０５）。结论：ＴａｎⅡＡ具有改善肾组织损伤、调节间质ＤＣ分布的作用，以低剂量最佳；而且后者是ＴａｎⅡＡ的作用机理。
Objective: To study the effect of Tan Ⅱ A against HS-RRI in rats. Methods: 30 Sprague-Dawley Rats were divided into five groups of large、middle、small dose of Tanll A,PEG400,24h after resuscitation, and each group had 6 rats. The amended model of Yu* s was maden made, then it was observed that was the effect of Tan H A by intraperitoneal injection on pathomorphology and DC. The difference was analysed between Tan HA and the 24h of resuscitation. Results: The Tan HA could improve renal pathomorphology, and adjust DC; the correlation of them was positive. The compare to the PEG and the 24h group had remarkable diffence( P< 0.05). Conclusion: Tan HA could improve renal pathomorphology and DC, the small dose was the best; and the action of DC could be its mechanism.
出处
《中国中西医结合肾病杂志》
2002年第1期13-15,共3页
Chinese Journal of Integrated Traditional and Western Nephrology
基金
广东省中医药管理局科研基金资助项目(No.99158)
关键词
丹参酮ⅡA
出血性休克
再灌注肾损伤
树突状细胞
Tanshinone-Ⅱ A Hemorrhagic shock-renal reperfusion injury dendritic cells SD-rat
