摘要
目的:了解小儿肾病综合征发病过程中血浆中NO,ET浓度的变化特点。方法:采用分光光度法及放射免疫分析法检测了27例单纯性肾病综合征患儿及20例健康对照儿童血浆中NO,ET浓度。结果:血浆NO,NOS,ET在肾病患儿,正常对照组分别为(44.90±9.74μmol/L,13.84±3.44 U/mL,194.41±46.42 pg/ml);(80.46±13.43μmol/L,32.20±3.80U/mL,79.02±13.37pg/ml)。肾病患儿NO,NOS值显著降低(P<0.01),ET值显著增高。NO与NOS呈正相关(r=0.8798),NO与ET呈负相关(r=-0.6965)。结论:血浆NO,ET的浓度变化在肾病综合征患儿的病理生理过程中起着一定作用。
Objective: To study the change patterns of plasma nitric oxide (NO) and endothelin-1 (ET) in children with nephrotic syndrome. Methods: The plasma NO and ET concentrations were determined in 27 children with nephrotic syndrome, and 20 healthy children as the control group by spectrophotometry and RIA. Results: 1.NO and NOS levels in patients with nephrotic syndrome (44.90±9.74μmol/L,13.84±3.44U/mL)were significantly higher as compared with those in the control group (80.46±13.43μmol/L,37.20±3.80U/mL).2.ET level in patients with nephrotic syndrome (194.41±46.42pg/ml)were significantly lower as compared with that in the control group(79.02±13.37pg/mL).3.Plasma NO was positively correlated with the plasma NOS(r=0.8798,P<0.01) and negatively correlated with the plasma ET(r=-0.6965, P<0.01). Conclusion: NO, NOS and ET play an important role in the nephrotice syndrome. NO levels in children with nephrotic syndrome had negatively relationship with ET, suggesting that NO and ET both might take part in the pathophysiology in nephrotic syndrome.
出处
《黑龙江医药科学》
2001年第6期9-10,共2页
Heilongjiang Medicine and Pharmacy
