摘要
目的 :探讨砂仁的促胃肠动力作用机制。方法 :32只Wistar大鼠随机分为砂仁组及对照组 ,分别给大鼠灌服砂仁水提液或蒸馏水 1、6h后 ,以葡聚糖蓝 2 0 0 0为胃肠内标记物观察大鼠胃肠动力变化 ,放射免疫分析法测定血、胃窦及空肠组织胃动素 (MTL)、P物质 (SP)的含量变化。结果 :灌服 1、6h后 ,大鼠胃肠动力显著增强 ,血浆、胃窦及空肠组织中MTL、SP的含量明显增加 ,上述变化均以灌服砂仁煎液 1h后显著 (P <0 .0 1) ,6h后有减弱趋势(P <0 .0 5 )。结论 :砂仁的促胃肠动力作用与血及胃肠道MTL。
OBJECTIVE:To study the prokinetic mechanisms of amomum villosum. METHODS:All 32 Wistar rats were randomly divided into amomum villosum group and control group and then were given amomum villosum decoction or distilled water. After 1 and 6 hours respectively, the gastrointestinal motility changes of rats were assayed by Dextran blue 2000 being as a indicator;contents of motilin(MTL),substance P(SP)in plasma,antrum and jejunum tissue were detected with radioimmunoassay. RESULTS:The gastrointestinal motility of rats was markedly enhanced (P<0.01 or P<0.05), the contents of MTL,SP increased significantly (P<0.01 or P<0.05) in plasma,antrum and jejunum tissue at 1 and 6 hours after amomum villosum decoction was given. The above changes were more obvious at 1 hour's than at 6 hour's. CONCLUSION:The kinetogenic effects of amomum villosum may be correlated to the increased contents of MTL and SP in plasma and gastrointestinal tract.
出处
《华西药学杂志》
CAS
CSCD
2001年第6期417-418,共2页
West China Journal of Pharmaceutical Sciences
基金
重庆市应用基础研究基金资助项目 (No 96 0 0 18)
