摘要
目的 探讨生长抑素八肽 (又称 Octreotide奥曲肽 ,商品名善宁 )在胰十二指肠切除术后抑制胰液的分泌、预防和治疗胰瘘的作用。方法 对照组 :1990年 1月至 1995年 4月收治的 31例胰十二指肠切除术 ,术后未应用生长抑素八肽 ;实验组 :1995年 5月至 1999年 12月收治的 45例胰十二指肠切除术 ,术后常规应用生长抑素八肽 0 .1m g,每 8h皮下注射一次。胰十二指肠切除术均采用 Child术式。结果 对照组术后胰液分泌为 2 35 .5 3± 111.77ml/d,实验组术后胰液分泌为 133.0 9±112 .35 ml/d,实验组术后胰液分泌比对照组显著减少 ,差异有显著性意义 ( P<0 .0 5 )。对照组术后发生胰瘘 4例 ,未应用善宁治疗 ,死亡 3例。实验组术后发生胰瘘 3例 ,常规应用善宁治疗 ,无死亡病例。结论 善宁用于胰十二指肠切除术术后抑制胰液分泌、预防胰十二指肠切除术后胰瘘的发生和治疗胰瘘疗效可靠 ,能够降低术后胰瘘的发生率和术后死亡率具有重要的临床应用价值。
Objective To explore the effect of sandostatin(octreotide)on inhibiting pancreatic secretion and preventing and curing pancreatic fistula in patients underwent pancreatodudenectomy.Methods Control group comprised 31 cases underwent pancreatodudenectomy at our department from Jan.1990 to Apr.1999 who were not given sandostatin postoperatively.Sandostatin group patients,underwent pancreatodudenectomy from May.1995 to Dec .1995.received 0.1 mg of sandostatin hypodermically every 8 hours a day after the operation.Child's pancreatodudenectomy was adopted in all the cases.Results Pancreatic secretions on postoperative days in sandostatin group (133.09±112.35 ml/d)were significantly lower than those in the control group(235.5±111.77 ml/d)(p<0.05).Pancreatic fistula occurred in 4 cases in the control group,p3 cases died.Pancreatic fistula occurred in 3 cases in sandostatin group,no death occurred.Conclusion Sando statin can definitely inhibit pancreatic secretion and prvent and cure pancreatic fistula in patients underwent pancreatodudenectomy.Postoperative administration of sandostatin is of clinical importance for reducing the mortality of pancreatodudenectomy.
出处
《肝胆外科杂志》
2001年第6期436-437,共2页
Journal of Hepatobiliary Surgery
