摘要
目的 评估高三尖杉酯碱 (homoharringtonine ,HH)作为青光眼滤过手术辅助药的中远期疗效和并发症。方法 采用前瞻性随机对照方法将 63例 ( 73只眼 )难治性青光眼随机分为HH组 3 2例 ( 3 7只眼 )和对照组 3 1例 ( 3 6只眼 )。所有病例均接受同一标准的小梁切除手术。术毕及术后HH组分次球结膜下注射高三尖杉酯碱 ,每次 0 1ml ( 0 1mg) ,对照组未用药。术后随访观察 5～ 8年 (平均 6 4年 )。采用寿命表分析法统计。结果 至最后一次复查时 ,HH组功能性滤过泡的累计百分率为 73 0 % ,对照组为 44 2 % (P <0 0 1 ) ;HH组手术成功的累计百分率为 75 7% ,对照组为 41 7% (P <0 0 1 )。用药组角膜上皮缺损发生率为 1 8 9% ,对照组为2 7% (P <0 0 5)。HH组薄壁滤过泡的发生率为 41 0 % ,对照组为 2 3 0 % (P <0 0 5)。结论 高三尖杉酯碱是一种有效、相对安全的难治性青光眼滤过手术的辅助药。
OBJECTIVE To evaluate medium-term and long-term effects and complications of homoharringtonine (HH) on antiglaucoma filtering surgery.METHODS In a prospective and randomized control clinical trial,63 patients(73 eyes)with refractory glaucoma were enrolled, thirty-two (37 eyes)of them were divided into HH group and thirty-one (36 eyes) into control group. Same fashion of trabeculectomy was performed in all patients. HH 0.1ml(0.1mg) was injected in subconjunctiva each time in operation and postoperation in the HH group, without injection in the control group. The average of follow-up period was 6.4years(range from 5 years to 8 years). Data were analyzed by the life-table method of Kaplan-Meier.RESULTS At the final follow-up time, the cumulative percentage of functioning bleb was 73.0% and 44.2%(P<0.01),the cumulative success probability was 75.7% and 41.7% in HH group and in the control group respectively(P<0.01). The rates of corneal erosion were 18.9% and 2.7% in HH group and control group respectively (P<0.05). The rates of thin wall bleb were 41.0% and 23.0% in HH group and control group respectively (P<0.05). CONCLUSIONS Homoharringtonine is one of effective and safe adjunctive agent in filtering surgery of refractory glaucoma.
出处
《中国中医眼科杂志》
2001年第4期202-205,共4页
China Journal of Chinese Ophthalmology
基金
卫生部科研基金 (0 5 5 730 9)
