摘要
目的 探讨经关节镜移植自体耳廓软骨块修复颞下颌关节骨软骨缺损的可行性与修复机制。方法 于12只猕猴获取一定量的自体耳廓软骨块 ,经关节镜植入关节骨软骨缺损区 ;4周、8周、12周和 2 4周后经组织学观察、免疫组织化学染色评价修复情况。结果 术后 8周 ,关节面缺损区基本与正常组织平齐。随着时间的推移 ,修复区软骨细胞数量逐渐减少 ,代之以成纤维细胞构成的胶原纤维 ;免疫组织化学染色II型胶原呈现弱阳性。结论软骨块移植可修复颞下颌关节骨软骨缺损 ,但修复组织为纤维软骨样组织 ,随时间推移 ,逐渐成为纤维组织。
Objective To study the feasibility and resurfacing ability of auricular cartilage transplantation for osteochondral defect of TMJ.Methods Arthroscopic auricular cartilage transplantations were undertaken in 12 rhesus monkeys(24 joints) to repair the osteochondral defects in TMJs. The repaired tissues were examined by gross examination, light microscope and immunohistochemistry(IHC) 4 weeks,8 weeks,12 weeks and 24 weeks,postoperatively. Results The defects were repaired 8 weeks after operation. As time goes on , the chondrocytes in defects declined and fibroblast inceased at the same time. The IHC showed slight positive stain of type-II collagen.Conclusions The osteochondral defects of TMJ can be restored by autologous auricular cartilage.The nature of repaired tissue was fibrocartilage like tissue at first and then fibrotic tissue.
出处
《上海口腔医学》
CAS
CSCD
2001年第3期260-262,共3页
Shanghai Journal of Stomatology
基金
上海市青年科技启明星计划资助项目
关键词
颞下颌关节
骨软骨
缺损
关节镜
软骨移植
Temporomandibular Joint
Osteochondral Defect
Arthroscope
Cartilage Transplantation
