摘要
目的 :研究伪麻黄碱和麻黄碱对主动脉的作用。方法 :兔和大鼠主动脉环离体实验。结果 :伪麻黄碱 (3× 10 -5～ 3× 10 -3mol.L 1)浓度依赖性收缩兔主动脉环的作用显著弱于相同浓度的麻黄碱。高浓度伪麻黄碱 (10 -4 mol.L-1)和同浓度麻黄碱均未观察到收缩大鼠主动脉环的作用。大鼠主动脉环经伪麻黄碱 (10 -4 mol.L-1)预处理后 ,对去甲肾上腺素 (3× 10 -8～ 3× 10 -5mol.L 1)收缩作用无显著影响 ,而经麻黄碱 (10 -4 mol.L-1)预处理后 ,低浓度 (3× 10 -8～ 10 -6mol.L-1)去甲肾上腺素的收缩作用受抑制 ,高浓度 (3× 10 -5moll .L 1)时的作用增强。结论
Objective:To study the actions of pseudo-ephedrine and ephedrine on isolated rabbit's and rat's aorta ring.Methods:The rings of rabbit's and rat's aorta were routinely isolated and their contractilities were recorded by LZ-6 recorder.Results:Dose-dependent rabbit's aorta ring contractility exerted by pseudo-ephedrine(3×10 -5 ～3×10 -3 mol.L 1 )was weaker than that of ephedrine.The contractile response of rat's aorta was not seen even at higher concentration(10 -4 mol.L 1 )of pseudo-ephedrine or ephedrine.The contradiction of rat's aorta elicited by noradrenaline(3×10 -8 ～3×10 -5 mol.L 1 )showed no significant change after pseudo-ephedrine(10 -4 mol.L 1 )preincubation,but showed decreasing at lower concentration(3×10 -8 ～3×10 -6 mol.L 1 )and increasing at higher concentration(3×10 -5 mol.L 1 )after ephedrine(10 -4 mol.L 1 )preincubation.Conclusion:The different actions of pseudo-ephedrine and ephedrine on rabbit's and rat's arota are presumably due to the difference of α-receptor subtype distribution
出处
《宁夏医学院学报》
2001年第5期318-319,共2页
Journal of Ningxia Medical College
关键词
伪麻黄碱
麻黄碱
大鼠
主动脉
Α受体
pseudo-ephedrine
ephedrine
rat
rabbit
aorta
α-receptor
