摘要
目的 探讨端粒酶作为脑膜瘤标志物 ,在肿瘤良恶性鉴别、恶性程度评估以及预后预测等方面的意义。方法 利用TRAP ELISA方法定量检测 14例脑膜瘤中端粒酶的活性 ,结合肿瘤的分类和患者的临床资料分析。另取正常脑组织标本 10例作为对照。结果 10例脑膜瘤中 ,1例复发者表现为端粒酶阳性 ( 10 % ) ,4例恶性脑膜瘤中 3例呈端粒酶阳性 ( 75 % ) ,两组之间比较差异有显著性 (P =0 .0 41) ,另外 1例脑膜肉瘤呈端粒酶阳性。 10例正常脑组织中未检测到端粒酶活性。结论 端粒酶活性的激活在恶性脑膜瘤中是常见的现象。端粒酶作为肿瘤标志物 ,在脑膜瘤的良恶性鉴别、恶性程度评估、预后预测等方面具有重要的意义。
Objective To explore telomerase activity in meningiomas and its significance in tumors classification gradation and prognosis.Methods Telomerase activity of meningiomas was detected quantitatively using telomerase polymerase enzyme linked immunoassay (TRAP ELISA).Combining with the data,such as histopathological classification and patients′ clinical materials,we discussed the possibility of telomerase used as tumor marker for differentiating benign from malignant tumors,evaluating malignancy,predicting prognosis in meningioma.Results In 10 meningiomas,one recurred meningioma was detected as telomerase positive(10%).3 of 4 (75%) malignant meningiomas were positive for telomerase expression.The differences between the two groups were significant(P=0.041).Aditionally,one meningosarcoma was telomerase positive.Telomerase activity was not detected in 10 normal brain tissues.Conclusion Reactivation of telomerase activity is a frequent event in malignant meningiomas.Telomerase acts as tumor marker in meningiomas,thus has important significance in differentating benign from malignant,evaluating malignancy,and predicting prognosis.
出处
《中国肿瘤临床与康复》
2001年第6期48-51,共4页
Chinese Journal of Clinical Oncology and Rehabilitation
