摘要
研究金诺芬分子结构、晶体结构、熔点与重结晶条件的相互联系。用多种溶剂进行重结晶。结果表明 :随重结晶条件改变 ,可以得到 112～ 114℃、118～ 12 0°C或 114～ 118℃等多种熔点的金诺芬 ,生成的金诺芬熔点主要取决于重结晶速度 ,与所用溶剂无关。改变重结晶速度 ,可使不同熔点的金诺芬互相转变。对不同熔点的金诺芬进行元素分析、比旋光度分析及1H NMR、13 C NMR、MS、IR分析 ,结果表明 ,不同熔点的金诺芬其分子结构完全一致。X 衍射表明 。
The paper studied the relationship of the molecular structure, crystal structure and melting point of auranofin under the recrystallization conditions.The recrystallization of auranofin in various solvents was carried out. It was found that polymorphic auranofin with different mp (112～114°C,118～120°C and 114～118°C...) could be obtained under different recrystallization conditions.The morphologys of auranofin depended mainly upon the recrystallization rate,not upon the kinds of solvents.The polymorphic auranofin with different mp could transform each other by the changing the recrystallization rate.The analysis of elements, specific rotatory power,IR, 1H NMR, 13 C NMR and MS showed that the polymorphic auranofin had identical molecular structure The examination of X ray diffraction showed that there were two forms of auranofin with different crystal systems.
出处
《中国药物化学杂志》
CAS
CSCD
2001年第6期336-339,359,共5页
Chinese Journal of Medicinal Chemistry
基金
国家‘九五’攻关课题 (95 72 2 2 6 0 1)
